Consumption of milk from cows immunized with intestinal bacteria influences age-related changes in immune competence in mice

A. Ishida, Yasunobu Yoshikai, S. Murosaki, Chiharu Kubo, Y. Hidaka, K. Nomoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Milk was obtained from nonimmunized cows and cows immunized with a mixture of various human gut bacteria. Each milk was administered orally to 2-mo-old C57BL/6 mice at a dose of 150 g · kg-1 · d-1 for either 6 or 16 mo. The study group had fewer enteric bacteria and a lower concentration of the serum antibodies against enteric bacteria compared with the control group at 8 and 18 mo of age. Furthermore, the study group at 18 mo old had a higher redirected cytotoxicity of intestinal intraepithelial lymphocytes, a higher proliferative response of mesenteric lymph nodes cells against mitogenic or alloantigenic stimulation and a greater ability of the spleen cells to produce anti-sheep erythrocytes IgG antibody after systemic immunization with sheep erythrocytes. A lower level of autoantibodies was observed at 8 mo and 18 mo of age in the study group compared with the control group. These results suggest that the senescence of the murine immune system may be delayed by consumption of milk from immunized cows.

Original languageEnglish
Pages (from-to)1875-1883
Number of pages9
JournalJournal of Nutrition
Volume122
Issue number9
DOIs
Publication statusPublished - Jan 1 1992

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Mental Competency
Milk
Enterobacteriaceae
Bacteria
Sheep
Erythrocytes
Control Groups
Aptitude
Antibodies
Inbred C57BL Mouse
Autoantibodies
Immune System
Immunization
Spleen
Immunoglobulin G
Lymph Nodes
Lymphocytes
Serum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Consumption of milk from cows immunized with intestinal bacteria influences age-related changes in immune competence in mice. / Ishida, A.; Yoshikai, Yasunobu; Murosaki, S.; Kubo, Chiharu; Hidaka, Y.; Nomoto, K.

In: Journal of Nutrition, Vol. 122, No. 9, 01.01.1992, p. 1875-1883.

Research output: Contribution to journalArticle

Ishida, A. ; Yoshikai, Yasunobu ; Murosaki, S. ; Kubo, Chiharu ; Hidaka, Y. ; Nomoto, K. / Consumption of milk from cows immunized with intestinal bacteria influences age-related changes in immune competence in mice. In: Journal of Nutrition. 1992 ; Vol. 122, No. 9. pp. 1875-1883.
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