Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice

Ryoko Yamamoto, Hisanori Minami, Hiromi Matsusaki, Mami Sakashita, Naoki Morita, Osamu Nishimiya, Naonobu Tsutsumi, Masashi Hosokawa, Yutaka Itabashi, Toshiro Matsui, Kazuhiro Ura

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Abstract

The beneficial health effects of edible sea urchin consumption in mice fed a normal (ND) or high-fat diet (HFD) were investigated in this study. Notably, sea urchin-administered (250, 500, 1000 mg/kg) mice exhibited lower body, liver, and visceral fat weights, lower plasma levels of aspartate aminotransferase and alanine aminotransferase, and lower hepatic triacylglycerol levels than those fed carboxymethyl cellulose (CMC). Despite the high levels of cholesterol found in sea urchins, intake of these organisms had no effect on plasma cholesterol levels among the mice tested. Additionally, sea urchin consumption resulted in enhanced levels of arachidonic acid and docosahexaenoic acid within mouse livers. Lastly, mice fed HFD with sea urchin (500 mg/kg) exhibited increased mRNA expression of uncoupling protein-1 within brown adipose tissue, compared with those fed HFD with CMC. In conclusion, consumption of sea urchin might provide a protective effect against the development of obesity and/or nonalcoholic fatty liver disease.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalJournal of Functional Foods
Volume47
DOIs
Publication statusPublished - Aug 1 2018

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Sea Urchins
Echinoidea
Weight Gain
weight gain
Body Weight
Lipids
liver
body weight
Liver
mice
High Fat Diet
high fat diet
lipids
Carboxymethylcellulose Sodium
carboxymethylcellulose
cholesterol
visceral fat
Brown Adipose Tissue
brown adipose tissue
Intra-Abdominal Fat

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice. / Yamamoto, Ryoko; Minami, Hisanori; Matsusaki, Hiromi; Sakashita, Mami; Morita, Naoki; Nishimiya, Osamu; Tsutsumi, Naonobu; Hosokawa, Masashi; Itabashi, Yutaka; Matsui, Toshiro; Ura, Kazuhiro.

In: Journal of Functional Foods, Vol. 47, 01.08.2018, p. 40-47.

Research output: Contribution to journalArticle

Yamamoto, R, Minami, H, Matsusaki, H, Sakashita, M, Morita, N, Nishimiya, O, Tsutsumi, N, Hosokawa, M, Itabashi, Y, Matsui, T & Ura, K 2018, 'Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice', Journal of Functional Foods, vol. 47, pp. 40-47. https://doi.org/10.1016/j.jff.2018.04.063
Yamamoto, Ryoko ; Minami, Hisanori ; Matsusaki, Hiromi ; Sakashita, Mami ; Morita, Naoki ; Nishimiya, Osamu ; Tsutsumi, Naonobu ; Hosokawa, Masashi ; Itabashi, Yutaka ; Matsui, Toshiro ; Ura, Kazuhiro. / Consumption of the edible sea urchin Mesocentrotus nudus attenuates body weight gain and hepatic lipid accumulation in mice. In: Journal of Functional Foods. 2018 ; Vol. 47. pp. 40-47.
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