Context-dependent bidirectional modulation of Wnt/β-catenin signaling

Tohru Ishitani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Wnt/β-catenin signaling is an evolutionarily conserved signaling system that controls cell proliferation, fate specification, differentiation, survival, and death. This signaling system is used repeatedly during embryogenesis and organogenesis and has diverse context-dependent functions in different aspects. Extensive investigations during the past three decades have clarified the core components that mediate Wnt/β-catenin signaling in all cells. However, to understand the mechanisms by which Wnt/β-catenin signaling exerts context-specific roles, it is also important to identify the context-dependent modulators of Wnt/β-catenin signaling. Recently, we and others discovered that Nemo-like kinase (NLK) and dimerization partner 1 (DP1) can regulate Wnt/β-catenin signaling positively and negatively in a cellular context-dependent manner and demonstrated that they play essential roles in embryonic development by fine-tuning cellular response to Wnt/β-catenin signaling. In this chapter, I summarize the function of the context-dependent bidirectional Wnt/β-catenin signaling modulators, with particular focus on NLK and DP1, and discuss the significance of the bidirectional modulation in embryonic development.

Original languageEnglish
Title of host publicationNew Principles in Developmental Processes
PublisherSpringer Japan
Pages213-225
Number of pages13
Volume9784431546344
ISBN (Electronic)9784431546344
ISBN (Print)4431546332, 9784431546337
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Catenins
Modulation
Embryonic Development
Dimerization
Phosphotransferases
Modulators
Organogenesis
Cell proliferation
Cell Proliferation
Tuning
Specifications
Control systems

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ishitani, T. (2014). Context-dependent bidirectional modulation of Wnt/β-catenin signaling. In New Principles in Developmental Processes (Vol. 9784431546344, pp. 213-225). Springer Japan. https://doi.org/10.1007/978-4-431-54634-4_16

Context-dependent bidirectional modulation of Wnt/β-catenin signaling. / Ishitani, Tohru.

New Principles in Developmental Processes. Vol. 9784431546344 Springer Japan, 2014. p. 213-225.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ishitani, T 2014, Context-dependent bidirectional modulation of Wnt/β-catenin signaling. in New Principles in Developmental Processes. vol. 9784431546344, Springer Japan, pp. 213-225. https://doi.org/10.1007/978-4-431-54634-4_16
Ishitani T. Context-dependent bidirectional modulation of Wnt/β-catenin signaling. In New Principles in Developmental Processes. Vol. 9784431546344. Springer Japan. 2014. p. 213-225 https://doi.org/10.1007/978-4-431-54634-4_16
Ishitani, Tohru. / Context-dependent bidirectional modulation of Wnt/β-catenin signaling. New Principles in Developmental Processes. Vol. 9784431546344 Springer Japan, 2014. pp. 213-225
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