Continual gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensive rats

Takayuki Kawato, Hideki Tanaka, Masaki Tabuchi, Kana Ooshima, Kumiko Nakai, Yoshihisa Yamashita, Masao Maeno

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalClinical and Experimental Hypertension
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 7 2013

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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