Continuous mixed venous oxygen saturation, not mean blood pressure, is associated with early bupivacaine cardiotoxicity in dogs

Jin Tae Kim, Ka Young Rhee, Jae Hyon Bahk, Sang Hwan Do, Young Jin Lim, Hong Ko, Kook Hyun Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate changes of continuous mixed venous oxygen saturation (cSvO2) and mean arterial blood pressure (MBP) in dogs with bupivacaine-induced cardiac depression. Methods: Bupivacaine was infused into pentobarbital-anesthetized mongrel dogs (n = 8) at a rate of 0.5 mg·kg-1·min-1 until the MBP was 40 mmHg or less (end of bupivacaine infusion; BIE). The infusion time was divided into the early period, first 30 min of bupivacaine infusion and the late period, which was from 30 min of bupivacaine infusion until BIE. cSvO2 was monitored using a fibreoptic pulmonary artery catheter, and MBP and cardiac output (CO) were measured every ten minutes after the initiation of bupivacaine infusion. Arterial blood gas, serum electrolyte and bupivacaine concentration were measured simultaneously. The relationships between CO and cSvO2, and of CO vs MBP were compared by regression analysis in the early and late periods. Results: The Pearson's correlation coefficients between CO and cSVO2 were 0.782 (P = 2.1 × 10-7) in the early period and 0.824 (P = 1.3 × 10-6) in the late period. The correlation coefficients between CO and MBP were 0.019 (P = 0.921) in the early period and 0.799 (P = 4.8 × 10-6) in the late period. Conclusions: cSvO2, but not MBP, is associated with CO changes in bupivacaine-induced cardiac depression during the early period of bupivacaine intoxication. Decrease of MBP with low cSvO2 observed during the late period might imply severe cardiac depression induced by bupivacaine infusion.

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalCanadian Journal of Anesthesia
Volume50
Issue number4
DOIs
Publication statusPublished - Jan 1 2003

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Bupivacaine
Arterial Pressure
Dogs
Oxygen
Blood Pressure
Cardiac Output
Cardiotoxicity
Pentobarbital
Electrolytes
Pulmonary Artery

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Continuous mixed venous oxygen saturation, not mean blood pressure, is associated with early bupivacaine cardiotoxicity in dogs. / Kim, Jin Tae; Rhee, Ka Young; Bahk, Jae Hyon; Do, Sang Hwan; Lim, Young Jin; Ko, Hong; Lee, Kook Hyun.

In: Canadian Journal of Anesthesia, Vol. 50, No. 4, 01.01.2003, p. 376-381.

Research output: Contribution to journalArticle

Kim, Jin Tae ; Rhee, Ka Young ; Bahk, Jae Hyon ; Do, Sang Hwan ; Lim, Young Jin ; Ko, Hong ; Lee, Kook Hyun. / Continuous mixed venous oxygen saturation, not mean blood pressure, is associated with early bupivacaine cardiotoxicity in dogs. In: Canadian Journal of Anesthesia. 2003 ; Vol. 50, No. 4. pp. 376-381.
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abstract = "Purpose: To investigate changes of continuous mixed venous oxygen saturation (cSvO2) and mean arterial blood pressure (MBP) in dogs with bupivacaine-induced cardiac depression. Methods: Bupivacaine was infused into pentobarbital-anesthetized mongrel dogs (n = 8) at a rate of 0.5 mg·kg-1·min-1 until the MBP was 40 mmHg or less (end of bupivacaine infusion; BIE). The infusion time was divided into the early period, first 30 min of bupivacaine infusion and the late period, which was from 30 min of bupivacaine infusion until BIE. cSvO2 was monitored using a fibreoptic pulmonary artery catheter, and MBP and cardiac output (CO) were measured every ten minutes after the initiation of bupivacaine infusion. Arterial blood gas, serum electrolyte and bupivacaine concentration were measured simultaneously. The relationships between CO and cSvO2, and of CO vs MBP were compared by regression analysis in the early and late periods. Results: The Pearson's correlation coefficients between CO and cSVO2 were 0.782 (P = 2.1 × 10-7) in the early period and 0.824 (P = 1.3 × 10-6) in the late period. The correlation coefficients between CO and MBP were 0.019 (P = 0.921) in the early period and 0.799 (P = 4.8 × 10-6) in the late period. Conclusions: cSvO2, but not MBP, is associated with CO changes in bupivacaine-induced cardiac depression during the early period of bupivacaine intoxication. Decrease of MBP with low cSvO2 observed during the late period might imply severe cardiac depression induced by bupivacaine infusion.",
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T1 - Continuous mixed venous oxygen saturation, not mean blood pressure, is associated with early bupivacaine cardiotoxicity in dogs

AU - Kim, Jin Tae

AU - Rhee, Ka Young

AU - Bahk, Jae Hyon

AU - Do, Sang Hwan

AU - Lim, Young Jin

AU - Ko, Hong

AU - Lee, Kook Hyun

PY - 2003/1/1

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N2 - Purpose: To investigate changes of continuous mixed venous oxygen saturation (cSvO2) and mean arterial blood pressure (MBP) in dogs with bupivacaine-induced cardiac depression. Methods: Bupivacaine was infused into pentobarbital-anesthetized mongrel dogs (n = 8) at a rate of 0.5 mg·kg-1·min-1 until the MBP was 40 mmHg or less (end of bupivacaine infusion; BIE). The infusion time was divided into the early period, first 30 min of bupivacaine infusion and the late period, which was from 30 min of bupivacaine infusion until BIE. cSvO2 was monitored using a fibreoptic pulmonary artery catheter, and MBP and cardiac output (CO) were measured every ten minutes after the initiation of bupivacaine infusion. Arterial blood gas, serum electrolyte and bupivacaine concentration were measured simultaneously. The relationships between CO and cSvO2, and of CO vs MBP were compared by regression analysis in the early and late periods. Results: The Pearson's correlation coefficients between CO and cSVO2 were 0.782 (P = 2.1 × 10-7) in the early period and 0.824 (P = 1.3 × 10-6) in the late period. The correlation coefficients between CO and MBP were 0.019 (P = 0.921) in the early period and 0.799 (P = 4.8 × 10-6) in the late period. Conclusions: cSvO2, but not MBP, is associated with CO changes in bupivacaine-induced cardiac depression during the early period of bupivacaine intoxication. Decrease of MBP with low cSvO2 observed during the late period might imply severe cardiac depression induced by bupivacaine infusion.

AB - Purpose: To investigate changes of continuous mixed venous oxygen saturation (cSvO2) and mean arterial blood pressure (MBP) in dogs with bupivacaine-induced cardiac depression. Methods: Bupivacaine was infused into pentobarbital-anesthetized mongrel dogs (n = 8) at a rate of 0.5 mg·kg-1·min-1 until the MBP was 40 mmHg or less (end of bupivacaine infusion; BIE). The infusion time was divided into the early period, first 30 min of bupivacaine infusion and the late period, which was from 30 min of bupivacaine infusion until BIE. cSvO2 was monitored using a fibreoptic pulmonary artery catheter, and MBP and cardiac output (CO) were measured every ten minutes after the initiation of bupivacaine infusion. Arterial blood gas, serum electrolyte and bupivacaine concentration were measured simultaneously. The relationships between CO and cSvO2, and of CO vs MBP were compared by regression analysis in the early and late periods. Results: The Pearson's correlation coefficients between CO and cSVO2 were 0.782 (P = 2.1 × 10-7) in the early period and 0.824 (P = 1.3 × 10-6) in the late period. The correlation coefficients between CO and MBP were 0.019 (P = 0.921) in the early period and 0.799 (P = 4.8 × 10-6) in the late period. Conclusions: cSvO2, but not MBP, is associated with CO changes in bupivacaine-induced cardiac depression during the early period of bupivacaine intoxication. Decrease of MBP with low cSvO2 observed during the late period might imply severe cardiac depression induced by bupivacaine infusion.

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