Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3)fucosyltransferase gene (FUT6) in human populations

Yoshiro Koda, Hidenori Tachida, Hao Pang, Yuhua Liu, Mikiko Soejima, Abbas A. Ghaderi, Osamu Takenaka, Hiroshi Kimura

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Abstract

The coding sequences (∼1 kb) of FUT2 [ABO-Secretor type α(1,2)fucosyltransferase] and of FUT6 [plasma α(1,3)fucosyltransferase] were analyzed for allelic polymorphism by direct sequencing in five populations. The nucleotide diversities of FUT2 estimated from pairwise sequence differences were 0.0045, 0.0042, 0.0042, 0.0009, and 0.0008 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. The nucleotide diversities of FUT6 were 0.0024, 0.0016, 0.0015, 0.0017, and 0.0020 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. At FUT2, excesses in pairwise sequence differences compared to the number of polymorphic sites as indicated by a significantly positive Tajima's D were observed in European-Africans and in Iranians. The data do not fit expectations of the equilibrium neutral model with an infinite number of sites. On the other hand, Tajima's D's at FUT6 in each of the five populations and at FUT2 in Africans, Chinese, and Japanese were not significantly different from zero. FST between the Asians and the others measured at FUT2 was higher than at FUT6. These results suggest that natural selection was responsible for the generation of the FUT2 polymorphism in European-Africans and in Iranians.

Original languageEnglish
Pages (from-to)747-756
Number of pages10
JournalGenetics
Volume158
Issue number2
Publication statusPublished - Jul 3 2001

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galactoside 3-fucosyltransferase
Nucleotides
Genetic Selection
Population
Genes
galactoside 2-alpha-L-fucosyltransferase

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Koda, Y., Tachida, H., Pang, H., Liu, Y., Soejima, M., Ghaderi, A. A., ... Kimura, H. (2001). Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3)fucosyltransferase gene (FUT6) in human populations. Genetics, 158(2), 747-756.

Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3)fucosyltransferase gene (FUT6) in human populations. / Koda, Yoshiro; Tachida, Hidenori; Pang, Hao; Liu, Yuhua; Soejima, Mikiko; Ghaderi, Abbas A.; Takenaka, Osamu; Kimura, Hiroshi.

In: Genetics, Vol. 158, No. 2, 03.07.2001, p. 747-756.

Research output: Contribution to journalArticle

Koda, Y, Tachida, H, Pang, H, Liu, Y, Soejima, M, Ghaderi, AA, Takenaka, O & Kimura, H 2001, 'Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3)fucosyltransferase gene (FUT6) in human populations', Genetics, vol. 158, no. 2, pp. 747-756.
Koda, Yoshiro ; Tachida, Hidenori ; Pang, Hao ; Liu, Yuhua ; Soejima, Mikiko ; Ghaderi, Abbas A. ; Takenaka, Osamu ; Kimura, Hiroshi. / Contrasting patterns of polymorphisms at the ABO-Secretor gene (FUT2) and plasma α(1,3)fucosyltransferase gene (FUT6) in human populations. In: Genetics. 2001 ; Vol. 158, No. 2. pp. 747-756.
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abstract = "The coding sequences (∼1 kb) of FUT2 [ABO-Secretor type α(1,2)fucosyltransferase] and of FUT6 [plasma α(1,3)fucosyltransferase] were analyzed for allelic polymorphism by direct sequencing in five populations. The nucleotide diversities of FUT2 estimated from pairwise sequence differences were 0.0045, 0.0042, 0.0042, 0.0009, and 0.0008 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. The nucleotide diversities of FUT6 were 0.0024, 0.0016, 0.0015, 0.0017, and 0.0020 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. At FUT2, excesses in pairwise sequence differences compared to the number of polymorphic sites as indicated by a significantly positive Tajima's D were observed in European-Africans and in Iranians. The data do not fit expectations of the equilibrium neutral model with an infinite number of sites. On the other hand, Tajima's D's at FUT6 in each of the five populations and at FUT2 in Africans, Chinese, and Japanese were not significantly different from zero. FST between the Asians and the others measured at FUT2 was higher than at FUT6. These results suggest that natural selection was responsible for the generation of the FUT2 polymorphism in European-Africans and in Iranians.",
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