Contribution of comparative fish studies to general endocrinology

Structure and function of some osmoregulatory hormones

Yoshio Takei, Akatsuki Kawakoshi, Takehiro Tsukada, Shinya Yuge, Maho Ogoshi, Koji Inoue, Susumu Hyodo, Hideo Bannai, Satoru Miyano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fish endocrinologists are commonly motivated to pursue their research driven by their own interests in these aquatic animals. However, the data obtained in fish studies not only satisfy their own interests but often contribute more generally to the studies of other vertebrates, including mammals. The life of fishes is characterized by the aquatic habitat, which demands many physiological adjustments distinct from the terrestrial life. Among them, body fluid regulation is of particular importance as the body fluids are exposed to media of varying salinities only across the thin respiratory epithelia of the gills. Endocrine systems play pivotal roles in the homeostatic control of body fluid balance. Judging from the habitat-dependent control mechanisms, some osmoregulatory hormones of fish should have undergone functional and molecular evolution during the ecological transition to the terrestrial life. In fact, water-regulating hormones such as vasopressin are essential for survival on the land, whereas ion-regulating hormones such as natriuretic peptides, guanylins and adrenomedullins are diversified and exhibit more critical functions in aquatic species. In this short review, we introduce some examples illustrating how comparative fish studies contribute to general endocrinology by taking advantage of such differences between fishes and tetrapods. In a functional context, fish studies often afford a deeper understanding of the essential actions of a hormone across vertebrate taxa. Using the natriuretic peptide family as an example, we suggest that more functional studies on fishes will bring similar rewards of understanding. At the molecular level, recent establishment of genome databases in fishes and mammals brings clues to the evolutionary history of hormone molecules via a comparative genomic approach. Because of the functional and molecular diversification of ion-regulating hormones in fishes, this approach sometimes leads to the discovery of new hormones in tetrapods as exemplified by adrenomedullin 2.

Original languageEnglish
Pages (from-to)787-798
Number of pages12
JournalJournal of Experimental Zoology Part A: Comparative Experimental Biology
Volume305
Issue number9
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

Fingerprint

endocrinology
hormones
fish
body fluids
natriuretic peptides
vertebrates
mammals
ions
respiratory mucosa
endocrine system
vasopressin
aquatic habitat
gills
salinity
genomics
history

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Contribution of comparative fish studies to general endocrinology : Structure and function of some osmoregulatory hormones. / Takei, Yoshio; Kawakoshi, Akatsuki; Tsukada, Takehiro; Yuge, Shinya; Ogoshi, Maho; Inoue, Koji; Hyodo, Susumu; Bannai, Hideo; Miyano, Satoru.

In: Journal of Experimental Zoology Part A: Comparative Experimental Biology, Vol. 305, No. 9, 01.09.2006, p. 787-798.

Research output: Contribution to journalArticle

Takei, Yoshio ; Kawakoshi, Akatsuki ; Tsukada, Takehiro ; Yuge, Shinya ; Ogoshi, Maho ; Inoue, Koji ; Hyodo, Susumu ; Bannai, Hideo ; Miyano, Satoru. / Contribution of comparative fish studies to general endocrinology : Structure and function of some osmoregulatory hormones. In: Journal of Experimental Zoology Part A: Comparative Experimental Biology. 2006 ; Vol. 305, No. 9. pp. 787-798.
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