Contribution of L-type Ca2+ channels to long-term enhancement of high K+-evoked release of dopamine from rat striatal slices

Schuichi Koizumi, Yasufumi Kataoka, Kazuhide Inoue, Masami Kohzuma, Masami Niwa, Kohtaro Taniyama

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Abstract

Pre-treatment with BAY K 8644, an L-type voltage-gated Ca2+ channels agonist, produced long-term enhancement (LTE) of over 2 h of high K+-evoked dopamine release from rat striatal slices. Exposure to BAY K 8644 under Ca2+-free conditions did not enhance this release. Thus, a transient activation of L-type voltage-gated Ca2+ channels followed by Ca2+ entry can trigger LTE of the evoked DA release from striatal tissues. This type of LTE in the striatum underlines the importance of presynaptic mechanisms, including L-type voltage-gated Ca2+ channels of 'long-term potentiation' expression.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalNeuroscience Letters
Volume187
Issue number2
DOIs
Publication statusPublished - Mar 3 1995
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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