Contribution of wall mechanics to the dynamic properties of aortic baroreceptors

T. Imaizumi, M. Sugimachi, Y. Harasawa, S. I. Ando, K. Sunagawa, Y. Hirooka, A. Takeshita

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Abstract

To examine the contribution of wall mechanics to dynamic properties of baroreceptors, we subdivided the transfer function of baroreceptors into two subsystems [aortic pressure to diameter and diameter to aortic depressor nerve activity (ANA)]. In six α-chloralose-anesthetized rabbits, we measured pressure, diameter, and ANA while randomly perturbing pressure. We obtained transfer functions (pressure to ANA, diameter to ANA, and pressure to diameter) by taking the ratio of crosspower spectrum to the input power spectrum (0.005-5 Hz). Below 3 Hz, the transfer function from pressure to ANA was nearly identical to that from diameter to ANA, whereas that from pressure to diameter was flat. Using transfer functions we could reproduce adaptation and hysteresis that were quantitatively similar between pressure-ANA transduction and diameter-ANA transduction. The pressure-diameter relationship was almost instantaneous and thus showed no hysteresis. In a second group of rabbits, the ratio of the shift of the hysteresis loop was unchanged by ouabain (40 μg/kg iv, n = 7). We conclude that the dynamic properties of baroreceptors may not be related to the wall mechanics or the Na+-K+-adenosinetriphosphatase activity.

Original languageEnglish
Pages (from-to)H872-H880
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume264
Issue number3 33-3
DOIs
Publication statusPublished - 1993

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Imaizumi, T., Sugimachi, M., Harasawa, Y., Ando, S. I., Sunagawa, K., Hirooka, Y., & Takeshita, A. (1993). Contribution of wall mechanics to the dynamic properties of aortic baroreceptors. American Journal of Physiology - Heart and Circulatory Physiology, 264(3 33-3), H872-H880. https://doi.org/10.1152/ajpheart.1993.264.3.h872