Control of cardiovascular differentiation by microRNAs

kisho ohtani, Stefanie Dimmeler

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalBasic Research in Cardiology
Volume106
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

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MicroRNAs
Stem Cells
Small Untranslated RNA
RNA Stability
Cardiomegaly
Cell Lineage
Cardiovascular System
Smooth Muscle
Homeostasis
Fibrosis
Maintenance
Apoptosis
Gene Expression

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Control of cardiovascular differentiation by microRNAs. / ohtani, kisho; Dimmeler, Stefanie.

In: Basic Research in Cardiology, Vol. 106, No. 1, 01.01.2011, p. 5-11.

Research output: Contribution to journalReview article

ohtani, kisho ; Dimmeler, Stefanie. / Control of cardiovascular differentiation by microRNAs. In: Basic Research in Cardiology. 2011 ; Vol. 106, No. 1. pp. 5-11.
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