Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The design of nano-and microstructures based on self-organization is a key area of research in the search for new biomaterials and biodevices,and such structures have a variety of potential applications in tissue engineering scaffolds and medical implants.3D scaffolds of appropriate pore size and porosities and with interconnected pores are required to facilitate cell adhesion, proliferation,differentiation,and eventual tissue regeneration in a natural manner.We have reported the honeycomb-patterned polymer film with highly regular pores that is formed by self-organization.The honeycomb films exerted a strong influence on cell morphology, proliferation,cytoskeleton, focal adhesion,and ECM production profiles.Our studies demonstrated that the neural stem / progenitor cells morphology,proliferation,and differentiation are controlled by the pore size of the honeycomb film.It is expected that the honeycomb films will have great potentials as biomaterials for tissue regeneration in a growth factor free proliferation process of stem cells.

Original languageEnglish
Title of host publicationBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
Pages390-393
Number of pages4
Publication statusPublished - Jul 21 2009
Externally publishedYes
Event2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
Duration: Jan 14 2009Jan 17 2009

Publication series

NameBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices

Other

Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
CountryPortugal
CityPorto
Period1/14/091/17/09

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering

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