TY - JOUR
T1 - Control of swarming of molecular robots
AU - Keya, Jakia Jannat
AU - Kabir, Arif Md Rashedul
AU - Inoue, Daisuke
AU - Sada, Kazuki
AU - Hess, Henry
AU - Kuzuya, Akinori
AU - Kakugo, Akira
N1 - Funding Information:
We thank Prof. A. Konagaya and the members of the Molecular Robotics Research Group for valuable discussions and S. Kono for assisting DNA syntheses. This work was financially supported by Grant-in-Aid for Scientific Research on Innovative Areas “Molecular Robotics” (JSPS KAKENHI Grant Number JP24104004) from Japan Society for the Promotion of Science (JSPS) and Grant-in-Aid for Challenging Exploratory Research (JSPS KAKENHI Grant Number 15K12135). H.H. was supported by NSF grant CMMI-1662329.
Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Recently we demonstrated swarming of a self-propelled biomolecular motor system microtubule (MT)-kinesin where interactions among thousands of motile MTs were regulated in a highly programmable fashion by using DNA as a processor. However, precise control of this potential system is yet to be achieved to optimize the swarm behavior. In this work, we systematically controlled swarming of MTs on kinesin adhered surface by different physicochemical parameters of MT-kinesin and DNA. Tuning the length of DNA sequences swarming was precisely controlled with thermodynamic and kinetic feasibility. In addition, swarming was regulated using different concentration of DNA crosslinkers. Reversibility of swarming was further controlled by changing the concentration of strand displacement DNA signal allowing dissociation of swarm. The control over the swarm was accompanied by variable stiffness of MTs successfully, providing translational and circular motion. Moreover, the morphology of swarm was also found to be changed not only depending on the stiffness but also body length of MTs. Such detail study of precise control of swarming would provide new insights in developing a promising molecular swarm robotic system with desired functions.
AB - Recently we demonstrated swarming of a self-propelled biomolecular motor system microtubule (MT)-kinesin where interactions among thousands of motile MTs were regulated in a highly programmable fashion by using DNA as a processor. However, precise control of this potential system is yet to be achieved to optimize the swarm behavior. In this work, we systematically controlled swarming of MTs on kinesin adhered surface by different physicochemical parameters of MT-kinesin and DNA. Tuning the length of DNA sequences swarming was precisely controlled with thermodynamic and kinetic feasibility. In addition, swarming was regulated using different concentration of DNA crosslinkers. Reversibility of swarming was further controlled by changing the concentration of strand displacement DNA signal allowing dissociation of swarm. The control over the swarm was accompanied by variable stiffness of MTs successfully, providing translational and circular motion. Moreover, the morphology of swarm was also found to be changed not only depending on the stiffness but also body length of MTs. Such detail study of precise control of swarming would provide new insights in developing a promising molecular swarm robotic system with desired functions.
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U2 - 10.1038/s41598-018-30187-1
DO - 10.1038/s41598-018-30187-1
M3 - Article
C2 - 30082825
AN - SCOPUS:85051248637
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 11756
ER -