Control of vascular endothelial cell function by changing the pore size of self-organized porous films

Emiko Itoh, Aiko Takayama, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Simomura

Research output: Contribution to conferencePaper

Abstract

Self-organized porous films (honeycomb films) with different pore size were prepared in order to investigate the influence of pore size on porcine arterial endothelial cells (PAECs) behavior. These films were fabricated by applying a moist air to a spread polymer solution containing biodegradable polymers (poly (ε-caprolactone)(PCL)) and an amphiphilic polymer. Four different pore sizes (5,10,12,16 μm) were prepared. Changes in cell morphology, proliferation, cytoskeleton and extra cellular matrix (ECM) (fibronectin, laminin, type IV collagen, elastin) production profiles were observed by optical, fluorescence, and scanning electron microscopy. The degree of spreading of PAECs was enhanced with increase of the pore size. PAECs proliferated on the honeycomb films. Almost the same ECM production profiles were obtained on the honeycomb films. These suggest that the honeycomb film is suitable as a material of a new vascular device.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Itoh, E., Takayama, A., Tanaka, M., Yamamoto, S., & Simomura, M. (2005). Control of vascular endothelial cell function by changing the pore size of self-organized porous films. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.