Control of vascular endothelial cell function by changing the pore size of self-organized porous films

Emiko Itoh, Aiko Takayama, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Simomura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Self-organized porous films (honeycomb films) with different pore size were prepared in order to investigate the influence of pore size on porcine arterial endothelial cells (PAECs) behavior. These films were fabricated by applying a moist air to a spread polymer solution containing biodegradable polymers (poly (ε-caprolactone)(PCL)) and an amphiphilic polymer. Four different pore sizes (5,10,12,16 μm) were prepared. Changes in cell morphology, proliferation, cytoskeleton and extra cellular matrix (ECM) (fibronectin, laminin, type IV collagen, elastin) production profiles were observed by optical, fluorescence, and scanning electron microscopy. The degree of spreading of PAECs was enhanced with increase of the pore size. PAECs proliferated on the honeycomb films. Almost the same ECM production profiles were obtained on the honeycomb films. These suggest that the honeycomb film is suitable as a material of a new vascular device.

Original languageEnglish
Title of host publication54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
Pages2234
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

Fingerprint

Endothelial cells
Pore size
Elastin
Biodegradable polymers
Polymer solutions
Collagen
Fluorescence
Scanning electron microscopy
Polymers
Air

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Itoh, E., Takayama, A., Tanaka, M., Yamamoto, S., & Simomura, M. (2005). Control of vascular endothelial cell function by changing the pore size of self-organized porous films. In 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2234)

Control of vascular endothelial cell function by changing the pore size of self-organized porous films. / Itoh, Emiko; Takayama, Aiko; Tanaka, Masaru; Yamamoto, Sadaaki; Simomura, Masatsugu.

54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 2234.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Itoh, E, Takayama, A, Tanaka, M, Yamamoto, S & Simomura, M 2005, Control of vascular endothelial cell function by changing the pore size of self-organized porous films. in 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan. 1 edn, vol. 54, pp. 2234, 54th SPSJ Annual Meeting 2005, Yokohama, Japan, 5/25/05.
Itoh E, Takayama A, Tanaka M, Yamamoto S, Simomura M. Control of vascular endothelial cell function by changing the pore size of self-organized porous films. In 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan. 1 ed. Vol. 54. 2005. p. 2234
Itoh, Emiko ; Takayama, Aiko ; Tanaka, Masaru ; Yamamoto, Sadaaki ; Simomura, Masatsugu. / Control of vascular endothelial cell function by changing the pore size of self-organized porous films. 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 2234
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