Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application

Shuji Yamashita, Hiromitsu Fukushima, Yasuyuki Akiyama, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Gold nanorods have strong absorption bands in the near-infrared region, in which light penetrates deeply into tissues. The absorbed light energy is converted into heat by gold nanorods, the so-called 'photothermal effect'. Hence, gold nanorods are expected to act not only as on-demand thermal converters for photothermal therapy but also as controllers of a drug-release system responding to irradiation by near-infrared light. To achieve a controlled-release system that can be triggered by light irradiation, double-stranded DNA (dsDNA) was modified on gold nanorods. When the dsDNA-modified gold nanorods were irradiated by near-infrared light, the single-stranded DNA (ssDNA) was released from gold nanorods due to the photothermal effect. The amount of released ssDNA was dependent upon the power and exposure time of light irradiation. Release of ssDNA was also observed in tumors grown on mice after light irradiation. Such a controlled-release system of oligonucleotide triggered by the photothermal effect could expand the applications of gold nanorods that have unique optical characteristics in medicinal fields.

Original languageEnglish
Pages (from-to)2130-2135
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number7
DOIs
Publication statusPublished - Apr 1 2011

Fingerprint

Nanotubes
Nanorods
Gold
Light
Irradiation
Single-Stranded DNA
Infrared radiation
Hot Temperature
Oligonucleotides
Tumors
Absorption spectra
Tissue
Controllers
DNA
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application. / Yamashita, Shuji; Fukushima, Hiromitsu; Akiyama, Yasuyuki; Niidome, Yasuro; Mori, Takeshi; Katayama, Yoshiki; Niidome, Takuro.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 7, 01.04.2011, p. 2130-2135.

Research output: Contribution to journalArticle

Yamashita, Shuji ; Fukushima, Hiromitsu ; Akiyama, Yasuyuki ; Niidome, Yasuro ; Mori, Takeshi ; Katayama, Yoshiki ; Niidome, Takuro. / Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 7. pp. 2130-2135.
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