TY - JOUR
T1 - Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application
AU - Yamashita, Shuji
AU - Fukushima, Hiromitsu
AU - Akiyama, Yasuyuki
AU - Niidome, Yasuro
AU - Mori, Takeshi
AU - Katayama, Yoshiki
AU - Niidome, Takuro
N1 - Funding Information:
This research was supported by a Grant-in-Aid of Scientific Research (B) (Grant Nos. 19300172 and 22300158 ) from the Japan Society for the Promotion of Science (JSPS) and by a Grant for Precursory Research for Embryonic Science and Technology (PRESTO) from the Japan Science and Technology Agency (JST) .
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Gold nanorods have strong absorption bands in the near-infrared region, in which light penetrates deeply into tissues. The absorbed light energy is converted into heat by gold nanorods, the so-called 'photothermal effect'. Hence, gold nanorods are expected to act not only as on-demand thermal converters for photothermal therapy but also as controllers of a drug-release system responding to irradiation by near-infrared light. To achieve a controlled-release system that can be triggered by light irradiation, double-stranded DNA (dsDNA) was modified on gold nanorods. When the dsDNA-modified gold nanorods were irradiated by near-infrared light, the single-stranded DNA (ssDNA) was released from gold nanorods due to the photothermal effect. The amount of released ssDNA was dependent upon the power and exposure time of light irradiation. Release of ssDNA was also observed in tumors grown on mice after light irradiation. Such a controlled-release system of oligonucleotide triggered by the photothermal effect could expand the applications of gold nanorods that have unique optical characteristics in medicinal fields.
AB - Gold nanorods have strong absorption bands in the near-infrared region, in which light penetrates deeply into tissues. The absorbed light energy is converted into heat by gold nanorods, the so-called 'photothermal effect'. Hence, gold nanorods are expected to act not only as on-demand thermal converters for photothermal therapy but also as controllers of a drug-release system responding to irradiation by near-infrared light. To achieve a controlled-release system that can be triggered by light irradiation, double-stranded DNA (dsDNA) was modified on gold nanorods. When the dsDNA-modified gold nanorods were irradiated by near-infrared light, the single-stranded DNA (ssDNA) was released from gold nanorods due to the photothermal effect. The amount of released ssDNA was dependent upon the power and exposure time of light irradiation. Release of ssDNA was also observed in tumors grown on mice after light irradiation. Such a controlled-release system of oligonucleotide triggered by the photothermal effect could expand the applications of gold nanorods that have unique optical characteristics in medicinal fields.
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U2 - 10.1016/j.bmc.2011.02.042
DO - 10.1016/j.bmc.2011.02.042
M3 - Article
C2 - 21421321
AN - SCOPUS:79953172174
SN - 0968-0896
VL - 19
SP - 2130
EP - 2135
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 7
ER -