Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

A series of block oligomers consisting of the same monomer composition but a different block sequence was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization to screen high affinity ligands for a toxic peptide. Activity and affinity screening of mono-, di-, and tri-block oligomers revealed that in addition to the localization and combination of functional groups, the sequence of the functional block and end groups are of significant importance to design the ligands that bind and neutralize the peptide.