CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection

Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Mayuko Ohuchi, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Yuji Miyamoto, Naoya Yoshida, Eiji Oki, Masayuki Watanabe, Hideo Baba

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection. Methods: Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined. Results: CONUT score correlated significantly with age (P < 0.001), body mass index (P = 0.005), carcinoembryonic antigen (P = 0.002), and carbohydrate antigen 19-9 (P = 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92; P < 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74; P < 0.001). Conclusions: CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalInternational Journal of Colorectal Disease
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Nutritional Status
Colorectal Neoplasms
Survival
Confidence Intervals
Light
Nutrition Assessment
Carcinoembryonic Antigen
Lymphocyte Count
Serum Albumin
Body Mass Index
Multivariate Analysis
Survival Rate
Odds Ratio
Cholesterol
Carbohydrates
Antigens

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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CONUT : a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection. / Tokunaga, Ryuma; Sakamoto, Yasuo; Nakagawa, Shigeki; Ohuchi, Mayuko; Izumi, Daisuke; Kosumi, Keisuke; Taki, Katsunobu; Higashi, Takaaki; Miyamoto, Yuji; Yoshida, Naoya; Oki, Eiji; Watanabe, Masayuki; Baba, Hideo.

In: International Journal of Colorectal Disease, Vol. 32, No. 1, 01.01.2017, p. 99-106.

Research output: Contribution to journalArticle

Tokunaga, R, Sakamoto, Y, Nakagawa, S, Ohuchi, M, Izumi, D, Kosumi, K, Taki, K, Higashi, T, Miyamoto, Y, Yoshida, N, Oki, E, Watanabe, M & Baba, H 2017, 'CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection', International Journal of Colorectal Disease, vol. 32, no. 1, pp. 99-106. https://doi.org/10.1007/s00384-016-2668-5
Tokunaga, Ryuma ; Sakamoto, Yasuo ; Nakagawa, Shigeki ; Ohuchi, Mayuko ; Izumi, Daisuke ; Kosumi, Keisuke ; Taki, Katsunobu ; Higashi, Takaaki ; Miyamoto, Yuji ; Yoshida, Naoya ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo. / CONUT : a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection. In: International Journal of Colorectal Disease. 2017 ; Vol. 32, No. 1. pp. 99-106.
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abstract = "Background: Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection. Methods: Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined. Results: CONUT score correlated significantly with age (P < 0.001), body mass index (P = 0.005), carcinoembryonic antigen (P = 0.002), and carbohydrate antigen 19-9 (P = 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 {\%} confidence interval (CI) 2.30–14.92; P < 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 {\%} CI 1.89–10.74; P < 0.001). Conclusions: CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.",
author = "Ryuma Tokunaga and Yasuo Sakamoto and Shigeki Nakagawa and Mayuko Ohuchi and Daisuke Izumi and Keisuke Kosumi and Katsunobu Taki and Takaaki Higashi and Yuji Miyamoto and Naoya Yoshida and Eiji Oki and Masayuki Watanabe and Hideo Baba",
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T2 - a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection

AU - Tokunaga, Ryuma

AU - Sakamoto, Yasuo

AU - Nakagawa, Shigeki

AU - Ohuchi, Mayuko

AU - Izumi, Daisuke

AU - Kosumi, Keisuke

AU - Taki, Katsunobu

AU - Higashi, Takaaki

AU - Miyamoto, Yuji

AU - Yoshida, Naoya

AU - Oki, Eiji

AU - Watanabe, Masayuki

AU - Baba, Hideo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection. Methods: Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined. Results: CONUT score correlated significantly with age (P < 0.001), body mass index (P = 0.005), carcinoembryonic antigen (P = 0.002), and carbohydrate antigen 19-9 (P = 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92; P < 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74; P < 0.001). Conclusions: CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.

AB - Background: Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection. Methods: Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined. Results: CONUT score correlated significantly with age (P < 0.001), body mass index (P = 0.005), carcinoembryonic antigen (P = 0.002), and carbohydrate antigen 19-9 (P = 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92; P < 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74; P < 0.001). Conclusions: CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.

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