Convenient synthesis of 3,7-diazabicyclo[3.3.1]nonane (bispidine)

Y. Miyahara, K. Goto, T. Inazu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Bispidine 1a is conveniently synthesized via a route involving double Mannich reaction of 1-allylpiperidin-4-one to N,N′-diallylbispidinone, Wolff-Kishner reduction of the bispidinone, and deallylation of the resulting N,N′-diallylbispidine by treatment with ethyl chloroformate in the presence of NaI, followed by alkaline hydrolysis.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalSynthesis
Issue number3
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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