Convergent evolution of AUA decoding in bacteria and archaea

Tsutomu Suzuki, Tomoyuki Numata

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Deciphering AUA codons is a difficult task for organisms, because AUA and AUG specify isoleucine (Ile) and methionine (Met), separately. Each of the other purine-ending sense codon sets (NNR) specifies a single amino acid in the universal genetic code. In bacteria and archaea, the cytidine derivatives, 2-lysylcytidine (L or lysidine) and 2-agmatinylcytidine (agm 2 C or agmatidine), respectively, are found at the first letter of the anticodon of tRNA Ile responsible for AUA codons. These modifications prevent base pairing with G of the third letter of AUG codon, and enable tRNA Ile to decipher AUA codon specifically. In addition, these modifications confer a charging ability of tRNA Ile with Ile. Despite their similar chemical structures, L and agm 2 C are synthesized by distinctive mechanisms and catalyzed by different classes of enzymes, implying that the analogous decoding systems for AUA codons were established by convergent evolution after the phylogenic split between bacteria and archaea-eukaryotes lineages following divergence from the last universal common ancestor (LUCA).

Original languageEnglish
Pages (from-to)1586-1596
Number of pages11
JournalRNA biology
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 1 2014
Externally publishedYes

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Archaea
Codon
Isoleucine
Bacteria
Transfer RNA
Transfer RNA Aminoacylation
Genetic Code
Anticodon
Cytidine
Eukaryota
Base Pairing
Methionine
Amino Acids
Enzymes
agmatidine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Convergent evolution of AUA decoding in bacteria and archaea. / Suzuki, Tsutomu; Numata, Tomoyuki.

In: RNA biology, Vol. 11, No. 12, 01.12.2014, p. 1586-1596.

Research output: Contribution to journalReview article

Suzuki, Tsutomu ; Numata, Tomoyuki. / Convergent evolution of AUA decoding in bacteria and archaea. In: RNA biology. 2014 ; Vol. 11, No. 12. pp. 1586-1596.
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