Convergent synthesis and biological activity of the WXYZA′B′ C′ ring system of maitotoxin

Tohru Oishi, Futoshi Hasegawa, Kohei Torikai, Keiichi Konoki, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

(Chemical Equation Presented) The WXYZA′B′C′ ring system (1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C′ ring fragments through construction of the XY and A′B′ ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.

Original languageEnglish
Pages (from-to)3599-3602
Number of pages4
JournalOrganic Letters
Volume10
Issue number16
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Convergent synthesis and biological activity of the WXYZA′B′ C′ ring system of maitotoxin'. Together they form a unique fingerprint.

  • Cite this