TY - JOUR
T1 - Convergent synthesis of the ABCDE ring system of ciguatoxin CTX3C
AU - Maruyama, Megumi
AU - Inoue, Masayuki
AU - Oishi, Tohru
AU - Oguri, Hiroki
AU - Ogasawara, Yoshihiro
AU - Shindo, Yumi
AU - Hirama, Masahiro
N1 - Funding Information:
We thank Dr Kenji Maeda for contributing to the preliminary phase of this work. A fellowship to M. M. from the Japanese Society for the Promotion of Science is gratefully acknowledged.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/3/4
Y1 - 2002/3/4
N2 - Ciguatoxin CTX3C is a representative congener of the ciguatoxins, which are known to be the principal causative-agents of ciguatera seafood poisoning. The structure of CTX3C spans over three nanometers and is characterized by thirteen ether rings. To attain a practical construction of this molecule, efficient supplies of the structural fragments are crucial. Herein we report the convergent synthesis of the ABCDE ring fragment featuring (i) alkylative coupling of the AB ring and E ring, and (ii) ring-closing olefin metathesis.
AB - Ciguatoxin CTX3C is a representative congener of the ciguatoxins, which are known to be the principal causative-agents of ciguatera seafood poisoning. The structure of CTX3C spans over three nanometers and is characterized by thirteen ether rings. To attain a practical construction of this molecule, efficient supplies of the structural fragments are crucial. Herein we report the convergent synthesis of the ABCDE ring fragment featuring (i) alkylative coupling of the AB ring and E ring, and (ii) ring-closing olefin metathesis.
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U2 - 10.1016/S0040-4020(02)00041-8
DO - 10.1016/S0040-4020(02)00041-8
M3 - Article
AN - SCOPUS:0037017773
SN - 0040-4020
VL - 58
SP - 1835
EP - 1851
JO - Tetrahedron
JF - Tetrahedron
IS - 10
ER -