Convergent synthesis of the cdef ring fragment of yessotoxin via α-cyano ethers

Tohru Oishi, Miho Suzuki, Koji Watanabe, Michio Murata

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The synthesis of the CDEF ring fragment of yessotoxin, a marine ladder polyether, has been achieved. Union of three components, the C ring aldehyde, the F ring diol, and trimethylsilyl cyanide, was accomplished by treatment with Sc(OTf) 3 to afford the α-cyano ether both in stepwise and one-pot reactions. The DE ring system was constructed through a ring closing metathesis reaction and reductive etherification sequence.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalHeterocycles
Volume69
Issue number1
DOIs
Publication statusPublished - Dec 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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