Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

Hiroto Imai, Hisatoshi Uehara, Masayuki Inoue, Hiroki Oguri, Tohru Oishi, Masahiro Hirama

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C-O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F ring.

Original languageEnglish
Pages (from-to)6219-6222
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number35
DOIs
Publication statusPublished - Aug 27 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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