Cooperation between different variants

A unique potential for virus evolution

Yuta Shirogane, Shumpei Watanabe, Yusuke Yanagi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

RNA viruses exist as quasispecies containing many variants within their populations because of the error prone nature of viral RNA-dependent RNA polymerases. Quasispecies are not a simple collection of individual variants. Instead, internal interactions among variants provide quasispecies with unique evolvability. An example is ‘cooperation’ between wild-type and defective measles viruses, in which co-existence of a wild-type and a mutant genome produces a new phenotype. Such internal interactions presuppose efficient co-transmission of multiple genomes to the same cell, which is achieved by polyploid virions of some virus families or by a high multiplicity of infection. Recent studies have revealed that multiple viral genomes can also be transmitted simultaneously (‘bloc transmission’) by other mechanisms, strengthening the concept of internal interactions among viral quasispecies. Elucidation of the mechanisms of virus evolution, including internal interactions and bloc transmission, may provide rational strategies to solve such important problems of virus infections as drug-resistance, immune evasion, and acquisition of the new tropism and host range.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalVirus Research
Volume264
DOIs
Publication statusPublished - Apr 15 2019

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Genome
Viruses
Defective Viruses
Immune Evasion
RNA Replicase
Measles virus
Tropism
Polyploidy
Viral Genome
Host Specificity
RNA Viruses
Viral RNA
Virus Diseases
Drug Resistance
Virion
Phenotype
Infection
Population

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Cooperation between different variants : A unique potential for virus evolution. / Shirogane, Yuta; Watanabe, Shumpei; Yanagi, Yusuke.

In: Virus Research, Vol. 264, 15.04.2019, p. 68-73.

Research output: Contribution to journalReview article

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