Copper-catalyzed synthesis of benzo[d]isothiazol-3(2H)-ones and N-acyl-benzothiazetidine by intramolecular dehydrogenative cyclization is described. In this reaction, a new nitrogen-sulfur (N-S) bond is formed by N-H/S-H coupling. The present reaction has high functional group tolerance and gives products in gram scale. This method promotes double cyclization, allowing for synthesis of a drug intermediate.
|Number of pages||6|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - Jul 19 2013|
All Science Journal Classification (ASJC) codes
- Organic Chemistry