Copper-catalyzed intramolecular N-S bond formation by oxidative dehydrogenative cyclization

Zhen Wang, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Copper-catalyzed synthesis of benzo[d]isothiazol-3(2H)-ones and N-acyl-benzothiazetidine by intramolecular dehydrogenative cyclization is described. In this reaction, a new nitrogen-sulfur (N-S) bond is formed by N-H/S-H coupling. The present reaction has high functional group tolerance and gives products in gram scale. This method promotes double cyclization, allowing for synthesis of a drug intermediate.

Original languageEnglish
Pages (from-to)7337-7342
Number of pages6
JournalJournal of Organic Chemistry
Issue number14
Publication statusPublished - Jul 19 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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