Copper-catalyzed N- and O-alkylation of amines and phenols using alkylborane reagents

Shunsuke Sueki, Yoichiro Kuninobu

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By the reaction of amines with alkylborane reagents in the presence of a catalytic amount of copper(II) acetate Cu(OAc)2 and di-tert-butyl peroxide, a cross-coupling reaction proceeded and alkylated amines were obtained in good to excellent yields. Phenols are also applicable for this reaction, and the corresponding alkyl aryl ethers were produced.

Original languageEnglish
Pages (from-to)1544-1547
Number of pages4
JournalOrganic Letters
Issue number7
Publication statusPublished - Apr 5 2013
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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