Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation

Zhen Wang, Yoichiro Kuninobu, Motomu Kanai

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

A copper-mediated terminal position-selective C-(sp3)-H acetoxylation using a bidentate directing group and AgOAc as an oxidant was achieved. This reaction has high functional group tolerance and is not affected by steric hindrance. The reaction proceeds in excellent yield, even in gram scale, and the directing group can be removed after the reaction. Aromatic C(sp2)-H acetoxylation also proceeded under similar reaction conditions.

Original languageEnglish
Pages (from-to)4790-4793
Number of pages4
JournalOrganic Letters
Volume16
Issue number18
DOIs
Publication statusPublished - Sep 19 2014

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Oxidants
Functional groups
Copper
copper

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation. / Wang, Zhen; Kuninobu, Yoichiro; Kanai, Motomu.

In: Organic Letters, Vol. 16, No. 18, 19.09.2014, p. 4790-4793.

Research output: Contribution to journalArticle

Wang, Zhen ; Kuninobu, Yoichiro ; Kanai, Motomu. / Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation. In: Organic Letters. 2014 ; Vol. 16, No. 18. pp. 4790-4793.
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