Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis

Takuro Kuriyama, Koji Kato, Keiji Sakamoto, Masayasu Hayashi, Shuichiro Takashima, Yasuo Mori, Katsuto Takenaka, Hiromi Iwasaki, Takanori Teshima, Naoki Harada, Koji Nagafuji, Toshihiro Miyamoto, Koichi Akashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Inherited hemophagocytic lymphohistiocytosis (HLH) is a genetic anomaly disorder in which abnormally activated cytotoxic T lymphocytes cannot induce the apoptosis of target cells and antigen-presenting cells, leading to hemophagocytosis, pancytopenia, and a variety of symptoms such as a high fever. The present patient with adult-onset HLH developed refractory disease despite receiving immunosuppressive treatments. He underwent a reduced-intensity conditioning (RIC) regimen that comprised antithymocyte globulin (ATG) followed by cord blood transplantation (RIC-CBT). He achieved and maintained a complete donor type. The incorporation of ATG into RIC-CBT may prevent graft failure and control hemophagocytosis, however, further efforts are necessary to reduce infectious complications.

Original languageEnglish
Pages (from-to)667-671
Number of pages5
JournalInternal Medicine
Volume55
Issue number6
DOIs
Publication statusPublished - Mar 15 2016

Fingerprint

Hemophagocytic Lymphohistiocytosis
Antilymphocyte Serum
Fetal Blood
Transplantation
Pancytopenia
Inborn Genetic Diseases
Cytotoxic T-Lymphocytes
Antigen-Presenting Cells
Immunosuppressive Agents
Fever
Tissue Donors
Apoptosis
Transplants
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis. / Kuriyama, Takuro; Kato, Koji; Sakamoto, Keiji; Hayashi, Masayasu; Takashima, Shuichiro; Mori, Yasuo; Takenaka, Katsuto; Iwasaki, Hiromi; Teshima, Takanori; Harada, Naoki; Nagafuji, Koji; Miyamoto, Toshihiro; Akashi, Koichi.

In: Internal Medicine, Vol. 55, No. 6, 15.03.2016, p. 667-671.

Research output: Contribution to journalArticle

Kuriyama, Takuro ; Kato, Koji ; Sakamoto, Keiji ; Hayashi, Masayasu ; Takashima, Shuichiro ; Mori, Yasuo ; Takenaka, Katsuto ; Iwasaki, Hiromi ; Teshima, Takanori ; Harada, Naoki ; Nagafuji, Koji ; Miyamoto, Toshihiro ; Akashi, Koichi. / Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis. In: Internal Medicine. 2016 ; Vol. 55, No. 6. pp. 667-671.
@article{3bd24e5881c848698e8109dd3729d640,
title = "Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis",
abstract = "Inherited hemophagocytic lymphohistiocytosis (HLH) is a genetic anomaly disorder in which abnormally activated cytotoxic T lymphocytes cannot induce the apoptosis of target cells and antigen-presenting cells, leading to hemophagocytosis, pancytopenia, and a variety of symptoms such as a high fever. The present patient with adult-onset HLH developed refractory disease despite receiving immunosuppressive treatments. He underwent a reduced-intensity conditioning (RIC) regimen that comprised antithymocyte globulin (ATG) followed by cord blood transplantation (RIC-CBT). He achieved and maintained a complete donor type. The incorporation of ATG into RIC-CBT may prevent graft failure and control hemophagocytosis, however, further efforts are necessary to reduce infectious complications.",
author = "Takuro Kuriyama and Koji Kato and Keiji Sakamoto and Masayasu Hayashi and Shuichiro Takashima and Yasuo Mori and Katsuto Takenaka and Hiromi Iwasaki and Takanori Teshima and Naoki Harada and Koji Nagafuji and Toshihiro Miyamoto and Koichi Akashi",
year = "2016",
month = "3",
day = "15",
doi = "10.2169/internalmedicine.55.5241",
language = "English",
volume = "55",
pages = "667--671",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "6",

}

TY - JOUR

T1 - Cord blood transplantation following reduced-intensity conditioning for adult-onset inherited hemophagocytic lymphohistiocytosis

AU - Kuriyama, Takuro

AU - Kato, Koji

AU - Sakamoto, Keiji

AU - Hayashi, Masayasu

AU - Takashima, Shuichiro

AU - Mori, Yasuo

AU - Takenaka, Katsuto

AU - Iwasaki, Hiromi

AU - Teshima, Takanori

AU - Harada, Naoki

AU - Nagafuji, Koji

AU - Miyamoto, Toshihiro

AU - Akashi, Koichi

PY - 2016/3/15

Y1 - 2016/3/15

N2 - Inherited hemophagocytic lymphohistiocytosis (HLH) is a genetic anomaly disorder in which abnormally activated cytotoxic T lymphocytes cannot induce the apoptosis of target cells and antigen-presenting cells, leading to hemophagocytosis, pancytopenia, and a variety of symptoms such as a high fever. The present patient with adult-onset HLH developed refractory disease despite receiving immunosuppressive treatments. He underwent a reduced-intensity conditioning (RIC) regimen that comprised antithymocyte globulin (ATG) followed by cord blood transplantation (RIC-CBT). He achieved and maintained a complete donor type. The incorporation of ATG into RIC-CBT may prevent graft failure and control hemophagocytosis, however, further efforts are necessary to reduce infectious complications.

AB - Inherited hemophagocytic lymphohistiocytosis (HLH) is a genetic anomaly disorder in which abnormally activated cytotoxic T lymphocytes cannot induce the apoptosis of target cells and antigen-presenting cells, leading to hemophagocytosis, pancytopenia, and a variety of symptoms such as a high fever. The present patient with adult-onset HLH developed refractory disease despite receiving immunosuppressive treatments. He underwent a reduced-intensity conditioning (RIC) regimen that comprised antithymocyte globulin (ATG) followed by cord blood transplantation (RIC-CBT). He achieved and maintained a complete donor type. The incorporation of ATG into RIC-CBT may prevent graft failure and control hemophagocytosis, however, further efforts are necessary to reduce infectious complications.

UR - http://www.scopus.com/inward/record.url?scp=84960949703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960949703&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.55.5241

DO - 10.2169/internalmedicine.55.5241

M3 - Article

C2 - 26984088

AN - SCOPUS:84960949703

VL - 55

SP - 667

EP - 671

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 6

ER -