Coronary Dilating Effects of Intracoronary Nicorandil: Comparison with Isosorbide Dinitrate

Jun Ichi Ejima, Toru Maruyama, Yoshikazu Kaji, Yasuo Tsuda, Shozo Kanaya, Takehiko Fujino, Yoshiyuki Niho, Koji Kaneda, Hidetoshi Moriyama, Ichiro Ohmura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from drat of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1.0 mg) in 46 patients with or widiout ischemic heart disease (IHD). Dose-dependent right coronary dilating action was observed by intracoronary administration of nicorandil widiout any adverse effects. The same degree of right coronary dilation was achieved by the intracoronary application of equivalent doses of ISDN. We conclude that intracoronary administration of nicorandil is beneficial for the supportive treatment of IHD during coronary artery investigation and intervention without the risk of severe systemic hypotension.

Original languageEnglish
Pages (from-to)699-707
Number of pages9
Journaljapanese heart journal
Volume36
Issue number6
DOIs
Publication statusPublished - Jan 1 1995

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Nicorandil
Isosorbide Dinitrate
Nitrates
Myocardial Ischemia
Hypotension
Dilatation
Coronary Vessels
Esters

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary Dilating Effects of Intracoronary Nicorandil : Comparison with Isosorbide Dinitrate. / Ejima, Jun Ichi; Maruyama, Toru; Kaji, Yoshikazu; Tsuda, Yasuo; Kanaya, Shozo; Fujino, Takehiko; Niho, Yoshiyuki; Kaneda, Koji; Moriyama, Hidetoshi; Ohmura, Ichiro.

In: japanese heart journal, Vol. 36, No. 6, 01.01.1995, p. 699-707.

Research output: Contribution to journalArticle

Ejima, JI, Maruyama, T, Kaji, Y, Tsuda, Y, Kanaya, S, Fujino, T, Niho, Y, Kaneda, K, Moriyama, H & Ohmura, I 1995, 'Coronary Dilating Effects of Intracoronary Nicorandil: Comparison with Isosorbide Dinitrate', japanese heart journal, vol. 36, no. 6, pp. 699-707. https://doi.org/10.1536/ihj.36.699
Ejima, Jun Ichi ; Maruyama, Toru ; Kaji, Yoshikazu ; Tsuda, Yasuo ; Kanaya, Shozo ; Fujino, Takehiko ; Niho, Yoshiyuki ; Kaneda, Koji ; Moriyama, Hidetoshi ; Ohmura, Ichiro. / Coronary Dilating Effects of Intracoronary Nicorandil : Comparison with Isosorbide Dinitrate. In: japanese heart journal. 1995 ; Vol. 36, No. 6. pp. 699-707.
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AU - Tsuda, Yasuo

AU - Kanaya, Shozo

AU - Fujino, Takehiko

AU - Niho, Yoshiyuki

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