Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma

Y. Kakeji, Y. Maehara, M. Morita, A. Matsukuma, M. Furusawa, I. Takahashi, T. Kusumoto, S. Ohno, K. Sugimachi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 ± 13.0%, 3.78 ± 0.98) in the STn-positive group than in the STn-negative group (34.2 ± 13.2%, 3.48 ± 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalBritish journal of cancer
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 1995

Fingerprint

Lymphatic Metastasis
Stomach
Staining and Labeling
Carcinoma
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Nucleolus Organizer Region
Nuclear Antigens
Proliferating Cell Nuclear Antigen
Survival Rate
sialosyl-Tn antigen
Serum

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kakeji, Y., Maehara, Y., Morita, M., Matsukuma, A., Furusawa, M., Takahashi, I., ... Sugimachi, K. (1995). Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma. British journal of cancer, 71(1), 191-195. https://doi.org/10.1038/bjc.1995.39

Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma. / Kakeji, Y.; Maehara, Y.; Morita, M.; Matsukuma, A.; Furusawa, M.; Takahashi, I.; Kusumoto, T.; Ohno, S.; Sugimachi, K.

In: British journal of cancer, Vol. 71, No. 1, 01.1995, p. 191-195.

Research output: Contribution to journalArticle

Kakeji, Y, Maehara, Y, Morita, M, Matsukuma, A, Furusawa, M, Takahashi, I, Kusumoto, T, Ohno, S & Sugimachi, K 1995, 'Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma', British journal of cancer, vol. 71, no. 1, pp. 191-195. https://doi.org/10.1038/bjc.1995.39
Kakeji, Y. ; Maehara, Y. ; Morita, M. ; Matsukuma, A. ; Furusawa, M. ; Takahashi, I. ; Kusumoto, T. ; Ohno, S. ; Sugimachi, K. / Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma. In: British journal of cancer. 1995 ; Vol. 71, No. 1. pp. 191-195.
@article{b342f35752754687ab7f55028b3a07b9,
title = "Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma",
abstract = "The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32{\%} (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 ± 13.0{\%}, 3.78 ± 0.98) in the STn-positive group than in the STn-negative group (34.2 ± 13.2{\%}, 3.48 ± 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.",
author = "Y. Kakeji and Y. Maehara and M. Morita and A. Matsukuma and M. Furusawa and I. Takahashi and T. Kusumoto and S. Ohno and K. Sugimachi",
year = "1995",
month = "1",
doi = "10.1038/bjc.1995.39",
language = "English",
volume = "71",
pages = "191--195",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma

AU - Kakeji, Y.

AU - Maehara, Y.

AU - Morita, M.

AU - Matsukuma, A.

AU - Furusawa, M.

AU - Takahashi, I.

AU - Kusumoto, T.

AU - Ohno, S.

AU - Sugimachi, K.

PY - 1995/1

Y1 - 1995/1

N2 - The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 ± 13.0%, 3.78 ± 0.98) in the STn-positive group than in the STn-negative group (34.2 ± 13.2%, 3.48 ± 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.

AB - The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 ± 13.0%, 3.78 ± 0.98) in the STn-positive group than in the STn-negative group (34.2 ± 13.2%, 3.48 ± 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0028796254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028796254&partnerID=8YFLogxK

U2 - 10.1038/bjc.1995.39

DO - 10.1038/bjc.1995.39

M3 - Article

C2 - 7819038

AN - SCOPUS:0028796254

VL - 71

SP - 191

EP - 195

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 1

ER -