Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma

Y. Kakeji, Y. Maehara, M. Morita, A. Matsukuma, M. Furusawa, I. Takahashi, T. Kusumoto, S. Ohno, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The expression of sialyl Tn (STn) antigen in 180 patients with Borrmann type IV gastric carcinomas was examined immunohistochemically. The rate of positive STn staining was 32% (57/180) for the primary tumours, and this positive staining correlated well with tumour extension, lymph node metastasis (P < 0.05) and peritoneal dissemination (P < 0.01). One-third (5/15) of patients with positive STn-staining cancer cells had a high level of serum STn. Lesions with positive STn staining were related to a lower survival rate for the patients (P < 0.05). Proliferative activity of the tumour, as measured by proliferating nuclear antigen (PCNA) labelling percentage and argyrophilic nucleolar organiser region (AgNOR) count, was significantly higher (41.5 ± 13.0%, 3.78 ± 0.98) in the STn-positive group than in the STn-negative group (34.2 ± 13.2%, 3.48 ± 0.85) (P < 0.01, P < 0.05 respectively). Estimating STn antigen may be useful for predicting the likelihood of lymph node metastasis or peritoneal dissemination and the clinical prognosis for patients with Borrmann type IV gastric carcinoma.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalBritish journal of cancer
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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