Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele

Nobuhiro Hidaka, Kiyomi Tsukimori, Satoshi Hojo, Yasuyuki Fujita, Yasuo Yumoto, Kouji Masumoto, Tomoaki Taguchi, Norio Wake

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims: To investigate the association between the presence of liver herniation and perinatal course and outcome of fetal omphalocele. Methods: Cases of fetal omphalocele managed at our hospital between 1990 and 2006 were retrospectively reviewed and grouped according to the location of the liver. Results: Thirty-three fetal omphalocele cases were diagnosed. The chromosomal status of 29 of 33 fetuses was determined. The rate of chromosomal abnormalities in cases with an extracorporeal liver was significantly lower (2/18) than in the intracorporeal group (6/11) (P=0.028). In chromosomally normal cases, four with extracorporeal liver resulted in early neonatal death compared to none with intracorporeal liver. Five of the 21 chromosomally normal fetuses showed an abnormal volume of amniotic fluid. All five cases had extracorporeal liver and two of them resulted in neonatal death. Conclusions: Fetuses with an extracorporeal liver had a lower rate of chromosomal abnormalities than those in the intracorporeal liver group. However, in chromosomally normal cases, it appeared that extracorporeal livers might be associated with more life-threatening anomalies, amniotic fluid volume abnormalities, and a higher rate of mortality than in the group with an intracorporeal liver. Upon diagnosis of fetal omphalocele, a careful search for liver location should be conducted before counseling.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalJournal of Perinatal Medicine
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Umbilical Hernia
Liver
Fetus
Amniotic Fluid
Chromosome Aberrations
Counseling

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele. / Hidaka, Nobuhiro; Tsukimori, Kiyomi; Hojo, Satoshi; Fujita, Yasuyuki; Yumoto, Yasuo; Masumoto, Kouji; Taguchi, Tomoaki; Wake, Norio.

In: Journal of Perinatal Medicine, Vol. 37, No. 1, 01.01.2009, p. 66-71.

Research output: Contribution to journalArticle

Hidaka, Nobuhiro ; Tsukimori, Kiyomi ; Hojo, Satoshi ; Fujita, Yasuyuki ; Yumoto, Yasuo ; Masumoto, Kouji ; Taguchi, Tomoaki ; Wake, Norio. / Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele. In: Journal of Perinatal Medicine. 2009 ; Vol. 37, No. 1. pp. 66-71.
@article{63ea7fbb94154ad8aee0082cc888b8f2,
title = "Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele",
abstract = "Aims: To investigate the association between the presence of liver herniation and perinatal course and outcome of fetal omphalocele. Methods: Cases of fetal omphalocele managed at our hospital between 1990 and 2006 were retrospectively reviewed and grouped according to the location of the liver. Results: Thirty-three fetal omphalocele cases were diagnosed. The chromosomal status of 29 of 33 fetuses was determined. The rate of chromosomal abnormalities in cases with an extracorporeal liver was significantly lower (2/18) than in the intracorporeal group (6/11) (P=0.028). In chromosomally normal cases, four with extracorporeal liver resulted in early neonatal death compared to none with intracorporeal liver. Five of the 21 chromosomally normal fetuses showed an abnormal volume of amniotic fluid. All five cases had extracorporeal liver and two of them resulted in neonatal death. Conclusions: Fetuses with an extracorporeal liver had a lower rate of chromosomal abnormalities than those in the intracorporeal liver group. However, in chromosomally normal cases, it appeared that extracorporeal livers might be associated with more life-threatening anomalies, amniotic fluid volume abnormalities, and a higher rate of mortality than in the group with an intracorporeal liver. Upon diagnosis of fetal omphalocele, a careful search for liver location should be conducted before counseling.",
author = "Nobuhiro Hidaka and Kiyomi Tsukimori and Satoshi Hojo and Yasuyuki Fujita and Yasuo Yumoto and Kouji Masumoto and Tomoaki Taguchi and Norio Wake",
year = "2009",
month = "1",
day = "1",
doi = "10.1515/JPM.2009.019",
language = "English",
volume = "37",
pages = "66--71",
journal = "Journal of Perinatal Medicine",
issn = "0300-5577",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "1",

}

TY - JOUR

T1 - Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele

AU - Hidaka, Nobuhiro

AU - Tsukimori, Kiyomi

AU - Hojo, Satoshi

AU - Fujita, Yasuyuki

AU - Yumoto, Yasuo

AU - Masumoto, Kouji

AU - Taguchi, Tomoaki

AU - Wake, Norio

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Aims: To investigate the association between the presence of liver herniation and perinatal course and outcome of fetal omphalocele. Methods: Cases of fetal omphalocele managed at our hospital between 1990 and 2006 were retrospectively reviewed and grouped according to the location of the liver. Results: Thirty-three fetal omphalocele cases were diagnosed. The chromosomal status of 29 of 33 fetuses was determined. The rate of chromosomal abnormalities in cases with an extracorporeal liver was significantly lower (2/18) than in the intracorporeal group (6/11) (P=0.028). In chromosomally normal cases, four with extracorporeal liver resulted in early neonatal death compared to none with intracorporeal liver. Five of the 21 chromosomally normal fetuses showed an abnormal volume of amniotic fluid. All five cases had extracorporeal liver and two of them resulted in neonatal death. Conclusions: Fetuses with an extracorporeal liver had a lower rate of chromosomal abnormalities than those in the intracorporeal liver group. However, in chromosomally normal cases, it appeared that extracorporeal livers might be associated with more life-threatening anomalies, amniotic fluid volume abnormalities, and a higher rate of mortality than in the group with an intracorporeal liver. Upon diagnosis of fetal omphalocele, a careful search for liver location should be conducted before counseling.

AB - Aims: To investigate the association between the presence of liver herniation and perinatal course and outcome of fetal omphalocele. Methods: Cases of fetal omphalocele managed at our hospital between 1990 and 2006 were retrospectively reviewed and grouped according to the location of the liver. Results: Thirty-three fetal omphalocele cases were diagnosed. The chromosomal status of 29 of 33 fetuses was determined. The rate of chromosomal abnormalities in cases with an extracorporeal liver was significantly lower (2/18) than in the intracorporeal group (6/11) (P=0.028). In chromosomally normal cases, four with extracorporeal liver resulted in early neonatal death compared to none with intracorporeal liver. Five of the 21 chromosomally normal fetuses showed an abnormal volume of amniotic fluid. All five cases had extracorporeal liver and two of them resulted in neonatal death. Conclusions: Fetuses with an extracorporeal liver had a lower rate of chromosomal abnormalities than those in the intracorporeal liver group. However, in chromosomally normal cases, it appeared that extracorporeal livers might be associated with more life-threatening anomalies, amniotic fluid volume abnormalities, and a higher rate of mortality than in the group with an intracorporeal liver. Upon diagnosis of fetal omphalocele, a careful search for liver location should be conducted before counseling.

UR - http://www.scopus.com/inward/record.url?scp=58149090855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149090855&partnerID=8YFLogxK

U2 - 10.1515/JPM.2009.019

DO - 10.1515/JPM.2009.019

M3 - Article

C2 - 18976045

AN - SCOPUS:58149090855

VL - 37

SP - 66

EP - 71

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

SN - 0300-5577

IS - 1

ER -