Correlation between the structure of water in the vicinity of carboxybetaine polymers and their biocompatibility

Susumu Tada, Takayuki Mori, Makoto Gemmei-Ide, Hiromi Kitano, Mitsuhiro Fukuda, Masaru Tanaka

Research output: Contribution to conferencePaperpeer-review

Abstract

Structure of water in the vicinity of carboxybetaine (CMB), n-buthyl methacrylate (BMA) polymers and their copolymers with various compositions was investigated by using vibrational spectroscopies. Raman spectroscopy has revealed that, in contrast with ordinary polyelectrolytes, the zwitterionic polymers, PCMB and water-soluble P(BMA/CMB), did not affect the hydrogen-bonded network structure of water in their aqueous solutions. ATR-IR spectra of water sorbed into the P(BMA/CMB) films was similar to that of free water, but that in PBMA film was not. The number of platelets adhered to the P(BMA/CMB) films was much smaller than that into PBMA film. These results suggest that the water structure is very important factor to generate biocompatibility of polymers.

Original languageEnglish
Pages3826-3827
Number of pages2
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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