Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes

Kentaro Suzuki, Takahisa Anada, Yoshitomo Honda, Koshi N. Kishimoto, Naohisa Miyatake, Masami Hosaka, Hideki Imaizumi, Eiji Itoi, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We have previously shown that synthetic octacalcium phosphate (OCP) displays highly osteoconductive and biodegradable characteristics. However, OCP cannot be sintered without thermal decomposition due to the existence of water molecules in the structure. The acquisition of the moldability and the improvement of the handling property in this material are subjects for the clinical use. In the present study, we prepared OCP complex with hyaluronic acid (Hya) that could be used in the injectable form and further examined the bone tissue reaction to cortical bone by placing the complex directly on an 8-weeks-old ICR mouse calvaria in comparison with the placement of OCP granules only. The granule form of OCP (between 300 to 500 μm in diameter) was mixed with sodium hyaluronic acid with molecular weights 90 x 104. The complex revealed an injectable characteristic if it was utilized in a syringe. After polytetrafluoroethylen ring was mounted on mouse calvaria, the inner space of the ring was filled with the complex and left the complex as it is for 6 weeks. Histological examination using the decalcified specimens indicated that the OCP/Hya complex exhibited greater bone formation than OCP granules only group within the ring at 6 weeks. The results suggested that the OCP/Hya complex could be used as an injectable and osteoconductive bone substitute material in many clinical situations.

Original languageEnglish
Title of host publicationBioceramics 24
Pages296-299
Number of pages4
Edition1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: Oct 21 2012Oct 24 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period10/21/1210/24/12

Fingerprint

Hyaluronic acid
Hyaluronic Acid
Bone
Phosphates
Tissue
Bone Substitutes
Syringes
octacalcium phosphate
Pyrolysis
Sodium
Molecular weight
Molecules
Water

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Suzuki, K., Anada, T., Honda, Y., Kishimoto, K. N., Miyatake, N., Hosaka, M., ... Suzuki, O. (2013). Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes. In Bioceramics 24 (1 ed., pp. 296-299). (Key Engineering Materials; Vol. 529-530, No. 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.296

Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes. / Suzuki, Kentaro; Anada, Takahisa; Honda, Yoshitomo; Kishimoto, Koshi N.; Miyatake, Naohisa; Hosaka, Masami; Imaizumi, Hideki; Itoi, Eiji; Suzuki, Osamu.

Bioceramics 24. 1. ed. 2013. p. 296-299 (Key Engineering Materials; Vol. 529-530, No. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Suzuki, K, Anada, T, Honda, Y, Kishimoto, KN, Miyatake, N, Hosaka, M, Imaizumi, H, Itoi, E & Suzuki, O 2013, Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes. in Bioceramics 24. 1 edn, Key Engineering Materials, no. 1, vol. 529-530, pp. 296-299, 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012, Fukuoka, Japan, 10/21/12. https://doi.org/10.4028/www.scientific.net/KEM.529-530.296
Suzuki K, Anada T, Honda Y, Kishimoto KN, Miyatake N, Hosaka M et al. Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes. In Bioceramics 24. 1 ed. 2013. p. 296-299. (Key Engineering Materials; 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.296
Suzuki, Kentaro ; Anada, Takahisa ; Honda, Yoshitomo ; Kishimoto, Koshi N. ; Miyatake, Naohisa ; Hosaka, Masami ; Imaizumi, Hideki ; Itoi, Eiji ; Suzuki, Osamu. / Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes. Bioceramics 24. 1. ed. 2013. pp. 296-299 (Key Engineering Materials; 1).
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