Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

P. L. Van Der Peet; Christian Gunawan; Shota Torigoe; Sho Yamasaki; Spencer J. Williams

doi:10.1039/c5cc00085h

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

P. L. Van Der Peet, Christian Gunawan, Shota Torigoe, Sho Yamasaki, Spencer J. Williams

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.

Original language	English
Pages (from-to)	5100-5103
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	24
DOIs	https://doi.org/10.1039/c5cc00085h
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.",

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AU - Van Der Peet, P. L.

AU - Gunawan, Christian

AU - Torigoe, Shota

AU - Yamasaki, Sho

AU - Williams, Spencer J.

PY - 2015

Y1 - 2015

N2 - An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.

AB - An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.

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Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

Abstract

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