Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

P. L. Van Der Peet, Christian Gunawan, Shota Torigoe, Sho Yamasaki, Spencer J. Williams

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2′S-isomer.

    Original languageEnglish
    Pages (from-to)5100-5103
    Number of pages4
    JournalChemical Communications
    Volume51
    Issue number24
    DOIs
    Publication statusPublished - 2015

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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