Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer

Yusuke Narita, Yukiko Matsushima, Takeru Shiroiwa, Koji Chiba, Yoichi Nakanishi, Tatsuo Kurokawa, Hisashi Urushihara

Research output: Contribution to journalArticle

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Abstract

Objectives: The combination use of gefitinib and epidermal growth factor receptor (EGFR) testing is a standard first-line therapy for patients with non-small cell lung cancer (NSCLC). Here, we examined the cost-effectiveness of this approach in Japan. Materials and methods: Our analysis compared the 'EGFR testing strategy', in which EGFR mutation testing was performed before treatment and patients with EGFR mutations received gefitinib while those without mutations received standard chemotherapy, to the 'no-testing strategy,' in which genetic testing was not conducted and all patients were treated with standard chemotherapy. A three-state Markov model was constructed to predict expected costs and outcomes for each strategy. We included only direct medical costs from the healthcare payer's perspective. Outcomes in the model were based on those reported in the Iressa Pan-Asia Study (IPASS). The incremental cost-effectiveness ratio (ICER) was calculated using quality-adjusted life-years (QALYs) gained. Sensitivity and scenario analyses were conducted. Results: The incremental cost and effectiveness per patient of the 'EGFR testing strategy' compared to the 'no-testing strategy' was estimated to be approximately JP¥122,000 (US$1180; US$1 = JP¥104 as of February 2014) and 0.036 QALYs. The ICER was then calculated to be around JP¥3.38 million (US$32,500) per QALY gained. These results suggest that the 'EGFR testing strategy' is cost-effective compared with the 'no-testing strategy' when JP¥5.0 million to 6.0 million per QALY gained is considered an acceptable threshold. These results were supported by the sensitivity and scenario analyses. Conclusion: The combination use of gefitinib and EGFR testing can be considered a cost-effective first-line therapy compared to chemotherapy such as carboplatin-paclitaxel for the treatment for NSCLC in Japan.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalLung Cancer
Volume90
Issue number1
DOIs
Publication statusPublished - Oct 1 2015

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Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cost-Benefit Analysis
Quality-Adjusted Life Years
Mutation
Costs and Cost Analysis
Drug Therapy
Therapeutics
Japan
Carboplatin
Genetic Testing
Paclitaxel
gefitinib
Health Care Costs

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Narita, Y., Matsushima, Y., Shiroiwa, T., Chiba, K., Nakanishi, Y., Kurokawa, T., & Urushihara, H. (2015). Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer. Lung Cancer, 90(1), 71-77. https://doi.org/10.1016/j.lungcan.2015.07.006

Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer. / Narita, Yusuke; Matsushima, Yukiko; Shiroiwa, Takeru; Chiba, Koji; Nakanishi, Yoichi; Kurokawa, Tatsuo; Urushihara, Hisashi.

In: Lung Cancer, Vol. 90, No. 1, 01.10.2015, p. 71-77.

Research output: Contribution to journalArticle

Narita, Y, Matsushima, Y, Shiroiwa, T, Chiba, K, Nakanishi, Y, Kurokawa, T & Urushihara, H 2015, 'Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer', Lung Cancer, vol. 90, no. 1, pp. 71-77. https://doi.org/10.1016/j.lungcan.2015.07.006
Narita, Yusuke ; Matsushima, Yukiko ; Shiroiwa, Takeru ; Chiba, Koji ; Nakanishi, Yoichi ; Kurokawa, Tatsuo ; Urushihara, Hisashi. / Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer. In: Lung Cancer. 2015 ; Vol. 90, No. 1. pp. 71-77.
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