TY - JOUR
T1 - Cost-efficiency analysis of voluntary vaccination against n-serovar diseases using antibody-dependent enhancement
T2 - A game approach
AU - Kabir, K. M.Ariful
AU - Tanimoto, Jun
N1 - Funding Information:
This study was partially supported by Grant-in-Aid for Scientific Research from JSPS , Japan, KAKENHI (Grant No. JP19KK0262 ), SCAT (Support Center for Advanced Telecommunications Technology) Research Foundation , and I/O Data Foundation awarded to Professor Tanimoto. We would like to express our gratitude to them.
Funding Information:
This study was partially supported by Grant-in-Aid for Scientific Research from JSPS, Japan, KAKENHI (Grant No. JP19KK0262), SCAT (Support Center for Advanced Telecommunications Technology) Research Foundation, and I/O Data Foundation awarded to Professor Tanimoto. We would like to express our gratitude to them. The data that support the findings of this study are available from the corresponding author upon reasonable request. Kabir K M Ariful conceived of the presented idea and established the theory and performed the computations. Jun Tanimoto encouraged Ariful Kabir to explore and supervised the findings of this work. All authors discussed the results and contributed to the final manuscript.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10/21
Y1 - 2020/10/21
N2 - Records of epidemics acknowledge immunological multi-serotype illnesses as an important aspect of the occurrence and control of contagious diseases. These patterns occur due to antibody-dependent-enhancement (ADE) among serotype diseases, which leads to infection of secondary infectious classes. One example of this is dengue hemorrhagic fever and dengue shock syndrome, which comprises the following four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. The evolutionary vaccination game approach is able to shed light on this long-standing issue in a bid to evaluate the success of various control programs. Although immunization is regarded as one of the most accepted approaches for minimizing the risk of infection, cost and efficiency are important factors that must also be considered. To analyze the n-serovar aspect alongside ADE consequence in voluntary vaccination, this study establishes a new mathematical epidemiological model that is dovetailed with evolutionary game theory, an approach through which we explored two vaccine programs: primary and secondary. Our findings illuminate that the ‘cost-efficiency’ effect for vaccination decision exhibits an impact on controlling n-serovar infectious diseases and should be designed in such a manner as to avoid adverse effects. Furthermore, our numerical result justifies the fact that adopting ADE significantly boosted emerging disease incidence, it also suggest that the joint vaccine policy works even better when the complex cyclical epidemic outbreak takes place among multi serotypes interactions. Research also exposes that the primary vaccine is a better controlling tool than the secondary; however, introducing a highly-efficiency secondary vaccine against secondary infection plays a key role to control the disease prevalence.
AB - Records of epidemics acknowledge immunological multi-serotype illnesses as an important aspect of the occurrence and control of contagious diseases. These patterns occur due to antibody-dependent-enhancement (ADE) among serotype diseases, which leads to infection of secondary infectious classes. One example of this is dengue hemorrhagic fever and dengue shock syndrome, which comprises the following four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. The evolutionary vaccination game approach is able to shed light on this long-standing issue in a bid to evaluate the success of various control programs. Although immunization is regarded as one of the most accepted approaches for minimizing the risk of infection, cost and efficiency are important factors that must also be considered. To analyze the n-serovar aspect alongside ADE consequence in voluntary vaccination, this study establishes a new mathematical epidemiological model that is dovetailed with evolutionary game theory, an approach through which we explored two vaccine programs: primary and secondary. Our findings illuminate that the ‘cost-efficiency’ effect for vaccination decision exhibits an impact on controlling n-serovar infectious diseases and should be designed in such a manner as to avoid adverse effects. Furthermore, our numerical result justifies the fact that adopting ADE significantly boosted emerging disease incidence, it also suggest that the joint vaccine policy works even better when the complex cyclical epidemic outbreak takes place among multi serotypes interactions. Research also exposes that the primary vaccine is a better controlling tool than the secondary; however, introducing a highly-efficiency secondary vaccine against secondary infection plays a key role to control the disease prevalence.
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U2 - 10.1016/j.jtbi.2020.110379
DO - 10.1016/j.jtbi.2020.110379
M3 - Article
C2 - 32622789
AN - SCOPUS:85087694414
VL - 503
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
M1 - 110379
ER -