Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement

Yoshihiro Matsumoto, Kenji Hiromatsu, Tetsu Sakai, Yasushi Kobayashi, Yuki Kimura, Jun Usami, Toru Shinzato, Kenji Maeda, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation‐induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co‐stimulation with LFA‐1 plays a key role in the choice between the two fates, differentiating between αβ and γδ T cells. Peripheral γδ T cells but not αβ T cells undergo apoptosis upon co‐cross‐linking of TcR and LFA‐1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of γδ T cells is inducible by combined stimuli independent of the Fas‐mediated pathway.

    Original languageEnglish
    Pages (from-to)2441-2445
    Number of pages5
    JournalEuropean Journal of Immunology
    Volume24
    Issue number10
    DOIs
    Publication statusPublished - Jan 1 1994

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    T-Cell Antigen Receptor
    Apoptosis
    T-Lymphocytes
    Cell Death

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Matsumoto, Y., Hiromatsu, K., Sakai, T., Kobayashi, Y., Kimura, Y., Usami, J., ... Yoshikai, Y. (1994). Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement. European Journal of Immunology, 24(10), 2441-2445. https://doi.org/10.1002/eji.1830241027

    Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement. / Matsumoto, Yoshihiro; Hiromatsu, Kenji; Sakai, Tetsu; Kobayashi, Yasushi; Kimura, Yuki; Usami, Jun; Shinzato, Toru; Maeda, Kenji; Yoshikai, Yasunobu.

    In: European Journal of Immunology, Vol. 24, No. 10, 01.01.1994, p. 2441-2445.

    Research output: Contribution to journalArticle

    Matsumoto, Y, Hiromatsu, K, Sakai, T, Kobayashi, Y, Kimura, Y, Usami, J, Shinzato, T, Maeda, K & Yoshikai, Y 1994, 'Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement', European Journal of Immunology, vol. 24, no. 10, pp. 2441-2445. https://doi.org/10.1002/eji.1830241027
    Matsumoto, Yoshihiro ; Hiromatsu, Kenji ; Sakai, Tetsu ; Kobayashi, Yasushi ; Kimura, Yuki ; Usami, Jun ; Shinzato, Toru ; Maeda, Kenji ; Yoshikai, Yasunobu. / Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement. In: European Journal of Immunology. 1994 ; Vol. 24, No. 10. pp. 2441-2445.
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