TY - JOUR
T1 - Co‐stimulation with LFA‐1 triggers apoptosis in γδ T cells on T cell receptor engagement
AU - Matsumoto, Yoshihiro
AU - Hiromatsu, Kenji
AU - Sakai, Tetsu
AU - Kobayashi, Yasushi
AU - Kimura, Yuki
AU - Usami, Jun
AU - Shinzato, Toru
AU - Maeda, Kenji
AU - Yoshikai, Yasunobu
PY - 1994/10
Y1 - 1994/10
N2 - Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation‐induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co‐stimulation with LFA‐1 plays a key role in the choice between the two fates, differentiating between αβ and γδ T cells. Peripheral γδ T cells but not αβ T cells undergo apoptosis upon co‐cross‐linking of TcR and LFA‐1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of γδ T cells is inducible by combined stimuli independent of the Fas‐mediated pathway.
AB - Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation‐induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co‐stimulation with LFA‐1 plays a key role in the choice between the two fates, differentiating between αβ and γδ T cells. Peripheral γδ T cells but not αβ T cells undergo apoptosis upon co‐cross‐linking of TcR and LFA‐1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of γδ T cells is inducible by combined stimuli independent of the Fas‐mediated pathway.
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U2 - 10.1002/eji.1830241027
DO - 10.1002/eji.1830241027
M3 - Article
C2 - 7925573
AN - SCOPUS:0028048351
SN - 0014-2980
VL - 24
SP - 2441
EP - 2445
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 10
ER -