Abstract
The addition of 100 μg/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV-EA activation and preserved the high viability of Raji cells. The attenuating effect of ECS was dose- dependent. The oral administration of ECS demonstrated an inhibitory effect on two-stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di-glucose ester were less potent than crocin in inhibiting the EBV- EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma. The effect of crocin was not mimicked by gentiobiose or glucose alone.
| Original language | English |
|---|---|
| Pages (from-to) | 400-404 |
| Number of pages | 5 |
| Journal | Phytotherapy Research |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Sep 1 1998 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
Cite this
Crocin and crocetin derivatives inhibit skin tumour promotion in mice. / Konoshima, T.; Takasaki, M.; Tokuda, H.; Morimoto, S.; Tanaka, H.; Kawata, E.; Xuan, L. J.; Saito, H.; Sugiura, M.; Molnar, J.; Shoyama, Y.
In: Phytotherapy Research, Vol. 12, No. 6, 01.09.1998, p. 400-404.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Crocin and crocetin derivatives inhibit skin tumour promotion in mice
AU - Konoshima, T.
AU - Takasaki, M.
AU - Tokuda, H.
AU - Morimoto, S.
AU - Tanaka, H.
AU - Kawata, E.
AU - Xuan, L. J.
AU - Saito, H.
AU - Sugiura, M.
AU - Molnar, J.
AU - Shoyama, Y.
PY - 1998/9/1
Y1 - 1998/9/1
N2 - The addition of 100 μg/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV-EA activation and preserved the high viability of Raji cells. The attenuating effect of ECS was dose- dependent. The oral administration of ECS demonstrated an inhibitory effect on two-stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di-glucose ester were less potent than crocin in inhibiting the EBV- EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma. The effect of crocin was not mimicked by gentiobiose or glucose alone.
AB - The addition of 100 μg/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV-EA activation and preserved the high viability of Raji cells. The attenuating effect of ECS was dose- dependent. The oral administration of ECS demonstrated an inhibitory effect on two-stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di-glucose ester were less potent than crocin in inhibiting the EBV- EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma. The effect of crocin was not mimicked by gentiobiose or glucose alone.
UR - http://www.scopus.com/inward/record.url?scp=7344261828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7344261828&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1573(199809)12:6<400::AID-PTR321>3.0.CO;2-4
DO - 10.1002/(SICI)1099-1573(199809)12:6<400::AID-PTR321>3.0.CO;2-4
M3 - Article
AN - SCOPUS:7344261828
VL - 12
SP - 400
EP - 404
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 6
ER -