Crocin promotes non-rapid eye movement sleep in mice

Mika Masaki, Kosuke Aritake, Hiroyuki Tanaka, Yukihiro Shoyama, Zhi Li Huang, Yoshihiro Urade

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L. In this study, we examined the sleep-promoting activity of crocin and crocetin by monitoring the locomotor activity and electroencephalogram after administration of these components to mice. Crocin (30 and 100 mg/kg) increased the total time of non-rapid eye movement (non-REM) sleep by 60 and 170%, respectively, during a 4-h period from 20:00 to 24:00 after its intraperitoneal administration at a lights-off time of 20:00. Crocetin (100 mg/kg) also increased the total time of non-REM sleep by 50% after the administration. These compounds did not change the amount of REM sleep or show any adverse effects, such as rebound insomnia, after the induction of sleep.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalMolecular Nutrition and Food Research
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

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