Cromakalim dilates rat cerebral arteries in vitro

Tetsuhiko Nagao, Seizo Sadoshima, Masahiro Kamouchi, Masatoshi Fujishima

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Using an in vitro perfusion method, we examined the effects of cromakalim, a potassium channel opener, on the superior cerebellar arteries of 24 rats. Cromakalim had no effect on contractions induced by 129 mM K+ until a concentration of 10-5 M was reached. Contractions evoked by 10-5 M serotonin were attenuated by cromakalim in a con centrat ion-dependent manner (p <0.05). The diameter of untreated superior cerebellar arteries remained almost constant with increasing perfusion pressure. However, in the presence of cromakalim, vessel diameter increased with increasing perfusion pressure. At concentrations of 3×10-6 M, cromakalim also inhibited basal myogenic tone and dilated unstimulated arteries (p <0.01). These results suggest that cromakalim is a cerebrovascular dilator acting on both receptor-mediated and myogenic contractions.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalStroke
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 1991

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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