Crosstalk of hedgehog and Wnt pathways in gastric cancer

Kosuke Yanai, Masafumi Nakamura, Takashi Akiyoshi, Shuntaro Nagai, Junji Wada, Kenichiro Koga, Hirokazu Noshiro, Eishi Nagai, Masazumi Tsuneyoshi, Masao Tanaka, Mitsuo Katano

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.

Original languageEnglish
Pages (from-to)145-156
Number of pages12
JournalCancer Letters
Volume263
Issue number1
DOIs
Publication statusPublished - May 8 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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