CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

Takahisa Tateishi, Ryo Yamasaki, Masahito Tanaka, Takuya Matsushita, Hitoshi Kikuchi, Noriko Isobe, Yasumasa Ohyagi, Jun ichi Kira

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalJournal of Neuroimmunology
Volume222
Issue number1-2
DOIs
Publication statusPublished - May 1 2010

Fingerprint

Amyotrophic Lateral Sclerosis
Chemokines
Cerebrospinal Fluid
Cytokines
Motor Neuron Disease
Immunoassay
Disease Progression
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. / Tateishi, Takahisa; Yamasaki, Ryo; Tanaka, Masahito; Matsushita, Takuya; Kikuchi, Hitoshi; Isobe, Noriko; Ohyagi, Yasumasa; Kira, Jun ichi.

In: Journal of Neuroimmunology, Vol. 222, No. 1-2, 01.05.2010, p. 76-81.

Research output: Contribution to journalArticle

@article{691fac5351d543c6811892198a393a14,
title = "CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis",
abstract = "We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.",
author = "Takahisa Tateishi and Ryo Yamasaki and Masahito Tanaka and Takuya Matsushita and Hitoshi Kikuchi and Noriko Isobe and Yasumasa Ohyagi and Kira, {Jun ichi}",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/j.jneuroim.2010.03.004",
language = "English",
volume = "222",
pages = "76--81",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis

AU - Tateishi, Takahisa

AU - Yamasaki, Ryo

AU - Tanaka, Masahito

AU - Matsushita, Takuya

AU - Kikuchi, Hitoshi

AU - Isobe, Noriko

AU - Ohyagi, Yasumasa

AU - Kira, Jun ichi

PY - 2010/5/1

Y1 - 2010/5/1

N2 - We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

AB - We measured the levels of 27 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) from 42 patients with sporadic amyotrophic lateral sclerosis (ALS), 12 patients with lower motor neuron disease (LMND), and 34 control patients with non-inflammatory neurological diseases (OND), using a multiplexed fluorescent bead-based immunoassay. Among cytokines/chemokines elevated in ALS, CCL2 and CXCL8 levels were negatively correlated with the revised ALS functional rating scale (ALSFRS-R) score, while CCL4 showed a positive correlation with ALSFRS-R score. CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS.

UR - http://www.scopus.com/inward/record.url?scp=77952289186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952289186&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2010.03.004

DO - 10.1016/j.jneuroim.2010.03.004

M3 - Article

C2 - 20381883

AN - SCOPUS:77952289186

VL - 222

SP - 76

EP - 81

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -