CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis

Takaaki Ishizu, Motozumi Minohara, Takashi Ichiyama, Ryutaro Kira, Masahito Tanaka, Manabu Osoegawa, Toshiro Hara, Susumu Furukawa, Jun ichi Kira

Research output: Contribution to journalArticle

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Abstract

We simultaneously measured 16 cytokines/chemokines in cerebrospinal fluid (CSF) from 14 patients with acute disseminated encephalomyelitis (ADEM) and 20 controls using a fluorescent bead-based immunoassay. A variety of cytokines, such as IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-γ, TNF-α, G-CSF and MIP-1β, were significantly elevated in ADEM. In particular, G-CSF showed a marked 38-fold increase compared to the control mean. Significant positive correlations with inflammatory parameters in CSF, such as cell counts and protein levels, were found for IFN-γ, IL-6 and IL-8. In contrast, IL-17 produced by activated CD4+ memory T cells was not increased. The results suggested that various cytokines related to activation of macrophages/microglias and Th1 and Th2 cells are upregulated in CSF in ADEM.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalJournal of Neuroimmunology
Volume175
Issue number1-2
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

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Acute Disseminated Encephalomyelitis
Chemokines
Cerebrospinal Fluid
Cytokines
Interleukin-8
Interleukin-6
Th2 Cells
Th1 Cells
Macrophage Activation
Interleukin-17
Interleukin-5
Interleukin-1
Immunoassay
Interleukin-4
Interleukin-10
Interleukin-2
Cell Count
T-Lymphocytes
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. / Ishizu, Takaaki; Minohara, Motozumi; Ichiyama, Takashi; Kira, Ryutaro; Tanaka, Masahito; Osoegawa, Manabu; Hara, Toshiro; Furukawa, Susumu; Kira, Jun ichi.

In: Journal of Neuroimmunology, Vol. 175, No. 1-2, 01.06.2006, p. 52-58.

Research output: Contribution to journalArticle

Ishizu, T, Minohara, M, Ichiyama, T, Kira, R, Tanaka, M, Osoegawa, M, Hara, T, Furukawa, S & Kira, JI 2006, 'CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis', Journal of Neuroimmunology, vol. 175, no. 1-2, pp. 52-58. https://doi.org/10.1016/j.jneuroim.2006.03.020
Ishizu T, Minohara M, Ichiyama T, Kira R, Tanaka M, Osoegawa M et al. CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. Journal of Neuroimmunology. 2006 Jun 1;175(1-2):52-58. https://doi.org/10.1016/j.jneuroim.2006.03.020
Ishizu, Takaaki ; Minohara, Motozumi ; Ichiyama, Takashi ; Kira, Ryutaro ; Tanaka, Masahito ; Osoegawa, Manabu ; Hara, Toshiro ; Furukawa, Susumu ; Kira, Jun ichi. / CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. In: Journal of Neuroimmunology. 2006 ; Vol. 175, No. 1-2. pp. 52-58.
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