CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders

Yoshihiko Kaneko, Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Hiroaki Kubota, Yuriko Hayashi-ogawa, Naohisa Miyakoshi, Tamami Yano, Kazuo Mishima, Tetsuo Shimizu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Narcolepsy and other sleep disorders are underrecognized in children; therefore, the final diagnosis and initiation of treatment is often delayed. This is due to the fact that the expression of sleep-related symptoms in children is often different from those of adults and polysomnography is generally difficult in children. CSF hypocretin-1 (orexin-A) measurement in adults demonstrated that low levels are highly specific to narcolepsy and this examination is now being established as a new diagnostic tool. In this study, we describe the spectrum of the hypocretin deficiency syndrome by analysis of CSF hypocretin-1 levels and clinical, polysomnography and human leukocyte antigen data in 38 pediatric and teenage patients with various sleep disorders and 120 patients with neurological conditions. The levels of CSF hypocretin-1 were significantly lower in narcolepsy compared to other neurological conditions. The measurement of hypocretin-1 is a useful diagnostic tool in pediatric narcolepsy, especially when other diagnostic information (e.g. polysomnography and human leukocyte antigen) is not sufficient.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalSleep and Biological Rhythms
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Fingerprint

Macrophage Colony-Stimulating Factor
Narcolepsy
Pediatrics
Polysomnography
HLA Antigens
sleep
signs and symptoms (animals and humans)
Orexins
Sleep Wake Disorders
narcolepsy
sleep disorders
Sleep
HLA antigens

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Neurology
  • Physiology

Cite this

Kaneko, Y., Kanbayashi, T., Arii, J., Kondo, H., Kubota, H., Hayashi-ogawa, Y., ... Shimizu, T. (2006). CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders. Sleep and Biological Rhythms, 4(2), 186-189. https://doi.org/10.1111/j.1479-8425.2006.00217.x

CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders. / Kaneko, Yoshihiko; Kanbayashi, Takashi; Arii, Junko; Kondo, Hideaki; Kubota, Hiroaki; Hayashi-ogawa, Yuriko; Miyakoshi, Naohisa; Yano, Tamami; Mishima, Kazuo; Shimizu, Tetsuo.

In: Sleep and Biological Rhythms, Vol. 4, No. 2, 06.2006, p. 186-189.

Research output: Contribution to journalArticle

Kaneko, Y, Kanbayashi, T, Arii, J, Kondo, H, Kubota, H, Hayashi-ogawa, Y, Miyakoshi, N, Yano, T, Mishima, K & Shimizu, T 2006, 'CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders', Sleep and Biological Rhythms, vol. 4, no. 2, pp. 186-189. https://doi.org/10.1111/j.1479-8425.2006.00217.x
Kaneko, Yoshihiko ; Kanbayashi, Takashi ; Arii, Junko ; Kondo, Hideaki ; Kubota, Hiroaki ; Hayashi-ogawa, Yuriko ; Miyakoshi, Naohisa ; Yano, Tamami ; Mishima, Kazuo ; Shimizu, Tetsuo. / CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders. In: Sleep and Biological Rhythms. 2006 ; Vol. 4, No. 2. pp. 186-189.
@article{905a77cce43c41dc8e4b9e4678c03892,
title = "CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders",
abstract = "Narcolepsy and other sleep disorders are underrecognized in children; therefore, the final diagnosis and initiation of treatment is often delayed. This is due to the fact that the expression of sleep-related symptoms in children is often different from those of adults and polysomnography is generally difficult in children. CSF hypocretin-1 (orexin-A) measurement in adults demonstrated that low levels are highly specific to narcolepsy and this examination is now being established as a new diagnostic tool. In this study, we describe the spectrum of the hypocretin deficiency syndrome by analysis of CSF hypocretin-1 levels and clinical, polysomnography and human leukocyte antigen data in 38 pediatric and teenage patients with various sleep disorders and 120 patients with neurological conditions. The levels of CSF hypocretin-1 were significantly lower in narcolepsy compared to other neurological conditions. The measurement of hypocretin-1 is a useful diagnostic tool in pediatric narcolepsy, especially when other diagnostic information (e.g. polysomnography and human leukocyte antigen) is not sufficient.",
author = "Yoshihiko Kaneko and Takashi Kanbayashi and Junko Arii and Hideaki Kondo and Hiroaki Kubota and Yuriko Hayashi-ogawa and Naohisa Miyakoshi and Tamami Yano and Kazuo Mishima and Tetsuo Shimizu",
year = "2006",
month = "6",
doi = "10.1111/j.1479-8425.2006.00217.x",
language = "English",
volume = "4",
pages = "186--189",
journal = "Sleep and Biological Rhythms",
issn = "1446-9235",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - CSF hypocretin-1 measurement in pediatric and teenage patients with sleep disorders

AU - Kaneko, Yoshihiko

AU - Kanbayashi, Takashi

AU - Arii, Junko

AU - Kondo, Hideaki

AU - Kubota, Hiroaki

AU - Hayashi-ogawa, Yuriko

AU - Miyakoshi, Naohisa

AU - Yano, Tamami

AU - Mishima, Kazuo

AU - Shimizu, Tetsuo

PY - 2006/6

Y1 - 2006/6

N2 - Narcolepsy and other sleep disorders are underrecognized in children; therefore, the final diagnosis and initiation of treatment is often delayed. This is due to the fact that the expression of sleep-related symptoms in children is often different from those of adults and polysomnography is generally difficult in children. CSF hypocretin-1 (orexin-A) measurement in adults demonstrated that low levels are highly specific to narcolepsy and this examination is now being established as a new diagnostic tool. In this study, we describe the spectrum of the hypocretin deficiency syndrome by analysis of CSF hypocretin-1 levels and clinical, polysomnography and human leukocyte antigen data in 38 pediatric and teenage patients with various sleep disorders and 120 patients with neurological conditions. The levels of CSF hypocretin-1 were significantly lower in narcolepsy compared to other neurological conditions. The measurement of hypocretin-1 is a useful diagnostic tool in pediatric narcolepsy, especially when other diagnostic information (e.g. polysomnography and human leukocyte antigen) is not sufficient.

AB - Narcolepsy and other sleep disorders are underrecognized in children; therefore, the final diagnosis and initiation of treatment is often delayed. This is due to the fact that the expression of sleep-related symptoms in children is often different from those of adults and polysomnography is generally difficult in children. CSF hypocretin-1 (orexin-A) measurement in adults demonstrated that low levels are highly specific to narcolepsy and this examination is now being established as a new diagnostic tool. In this study, we describe the spectrum of the hypocretin deficiency syndrome by analysis of CSF hypocretin-1 levels and clinical, polysomnography and human leukocyte antigen data in 38 pediatric and teenage patients with various sleep disorders and 120 patients with neurological conditions. The levels of CSF hypocretin-1 were significantly lower in narcolepsy compared to other neurological conditions. The measurement of hypocretin-1 is a useful diagnostic tool in pediatric narcolepsy, especially when other diagnostic information (e.g. polysomnography and human leukocyte antigen) is not sufficient.

UR - http://www.scopus.com/inward/record.url?scp=33845445744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845445744&partnerID=8YFLogxK

U2 - 10.1111/j.1479-8425.2006.00217.x

DO - 10.1111/j.1479-8425.2006.00217.x

M3 - Article

AN - SCOPUS:33845445744

VL - 4

SP - 186

EP - 189

JO - Sleep and Biological Rhythms

JF - Sleep and Biological Rhythms

SN - 1446-9235

IS - 2

ER -