C1-symmetric Rh/Phebox-catalyzed asymmetric alkynylation of α-ketoesters

Takashi Ohshima, Takahito Kawabata, Yosuke Takeuchi, Takahiro Kakinuma, Takanori Iwasaki, Takayuki Yonezawa, Hajime Murakami, Hisao Nishiyama, Kazushi Mashima

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Abstract

Thinking outside the box: A newly developed C1-symmetric Rh/Phebox complex efficiently catalyzed the asymmetric alkynylation of α-ketoester 1 with various aryl and alkyl substituted terminal alkynes to provide the corresponding chiral tertiary propargylic alcohols with up to 99 % ee (see scheme; TMS=trimethylsilyl).

Original languageEnglish
Pages (from-to)6296-6300
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number28
DOIs
Publication statusPublished - Jul 4 2011

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Ohshima, T., Kawabata, T., Takeuchi, Y., Kakinuma, T., Iwasaki, T., Yonezawa, T., ... Mashima, K. (2011). C1-symmetric Rh/Phebox-catalyzed asymmetric alkynylation of α-ketoesters. Angewandte Chemie - International Edition, 50(28), 6296-6300. https://doi.org/10.1002/anie.201100252