TY - JOUR
T1 - CT prediction of histological grade of hypervascular hepatocellular carcinoma
T2 - Utility of the portal phase
AU - Nishie, Akihiro
AU - Yoshimitsu, Kengo
AU - okamoto, daisuke
AU - Tajima, Tsuyoshi
AU - Asayama, Yoshiki
AU - Ishigami, Kousei
AU - Kakihara, Daisuke
AU - Nakayama, Tomohiro
AU - Takayama, Yukihisa
AU - Shirabe, Ken
AU - Fujita, Nobuhiro
AU - Honda, Hiroshi
PY - 2013/2
Y1 - 2013/2
N2 - Purpose: To elucidate whether the attenuation of hypervascular hepatocellular carcinoma (HCC) on the portal phase of dynamic CT is correlated with histological grade. Materials and methods: This study group consisted of 66 patients with 74 surgically resected, hypervascular HCCs. On a preoperative dynamic study with a 64-multidetector row CT, the portal phase was scanned 60 s after injecting the contrast agent following the pre-contrast image and hepatic arterial phase. The tumor attenuation of each HCC on the portal phase was categorized into high, iso-, or low, and was compared with the predominant histological grade using Mann-Whitney's U test. Results: Twenty-nine, 29, and 16 HCCs showed high, iso-, and low attenuation on the portal phase, respectively. Tumors were classified into three well- (w-), 58 moderately (m-), or 13 poorly (p-) differentiated HCCs. The tumor attenuation of p-HCC on the portal phase was significantly lower than those of w-HCC and m-HCC (p < 0.05 and p < 0.00001). Conclusion: The tumor attenuation on the portal phase may help when diagnosing the histological grade of hypervascular HCC. p-HCC are considered to show a faster contrast washout than w-HCC and m-HCC.
AB - Purpose: To elucidate whether the attenuation of hypervascular hepatocellular carcinoma (HCC) on the portal phase of dynamic CT is correlated with histological grade. Materials and methods: This study group consisted of 66 patients with 74 surgically resected, hypervascular HCCs. On a preoperative dynamic study with a 64-multidetector row CT, the portal phase was scanned 60 s after injecting the contrast agent following the pre-contrast image and hepatic arterial phase. The tumor attenuation of each HCC on the portal phase was categorized into high, iso-, or low, and was compared with the predominant histological grade using Mann-Whitney's U test. Results: Twenty-nine, 29, and 16 HCCs showed high, iso-, and low attenuation on the portal phase, respectively. Tumors were classified into three well- (w-), 58 moderately (m-), or 13 poorly (p-) differentiated HCCs. The tumor attenuation of p-HCC on the portal phase was significantly lower than those of w-HCC and m-HCC (p < 0.05 and p < 0.00001). Conclusion: The tumor attenuation on the portal phase may help when diagnosing the histological grade of hypervascular HCC. p-HCC are considered to show a faster contrast washout than w-HCC and m-HCC.
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U2 - 10.1007/s11604-012-0149-5
DO - 10.1007/s11604-012-0149-5
M3 - Article
C2 - 23070581
AN - SCOPUS:84878406667
VL - 31
SP - 89
EP - 98
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
SN - 1867-1071
IS - 2
ER -