Cu(II)-catalyzed acylation by thiol esters under neutral conditions: Tandem acylation-wittig reaction leading to a one-pot synthesis of butenolides

Kazumasa Matsuo, Mitsuru Shindo

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The first catalytic acylation of alcohols with a thiol ester present in Wittig reagents under neutral conditions catalyzed by the Cu(II) salt through a push-pull mechanism is reported. Furthermore, a new methodology for the one-pot lactonization of acyloins by a copper catalyst is developed. The synthetic utility of this method for the synthesis of natural products is shown.

Original languageEnglish
Pages (from-to)5346-5349
Number of pages4
JournalOrganic letters
Volume12
Issue number22
DOIs
Publication statusPublished - Nov 19 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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