Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice

Takumi Ishida, Junko Taketoh, Emi Nakatsune, Shoko Kan-o, Eri Naito, Shuso Takeda, Junpei Mutoh, Yuji Ishii, Hideyuki Yamada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The protective effect of curcumin, a potent inducer of heat shock protein (Hsp) 70, against the acute toxicity produced by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) was studied in vivo in C57BL/6J mice. Curcumin reduced the loss of body weight gain produced by TCDD regardless of having no effect on hepatomegaly and thymic atrophy. Hsp70.1 mRNA levels in liver and intestine were unaffected or tended to be reduced by TCDD and/or curcumin treatment. Curcumin also had no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that curcumin exhibits a protective effect against some forms of dioxin toxicity by a mechanism(s) distinct from the increase in hepatic and intestinal Hsp70 and inhibition of arylhydrocarbon receptor activation.

Original languageEnglish
Pages (from-to)474-482
Number of pages9
JournalJournal of Health Science
Volume50
Issue number5
DOIs
Publication statusPublished - Oct 1 2004

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Ishida, T., Taketoh, J., Nakatsune, E., Kan-o, S., Naito, E., Takeda, S., Mutoh, J., Ishii, Y., & Yamada, H. (2004). Curcumin anticipates the suppressed body weight gain with 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. Journal of Health Science, 50(5), 474-482. https://doi.org/10.1248/jhs.50.474