TY - JOUR
T1 - Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal
AU - Koirala, Sweta
AU - Nakano, Masayuki
AU - Arima, Hiroaki
AU - Takeuchi, Shouhei
AU - Ichikawa, Tomo
AU - Nishimura, Takayuki
AU - Ito, Hiromu
AU - Pandey, Basu Dev
AU - Pandey, Kishor
AU - Wada, Takayuki
AU - Yamamoto, Taro
N1 - Funding Information:
This work was supported by JSPS KAKENHI grant numbers 16H07075 and 17H04659, Grant-in-aid of Asia-Oceania collaborative research from Kanae foundation for the promotion of medical science, the research grant from the Japan Prize Foundation, the Joint Usage/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki University (2017-Ippan-29), and Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University.
Publisher Copyright:
© The Author(s).
PY - 2018/2/21
Y1 - 2018/2/21
N2 - Background: Epidemiology of noncommunicable diseases (NCDs) such as obesity and diabetes mellitus (DM) are influenced by multiple hosts and environmental factors. This study aims to investigate the prevalence of NCDs and determine their risk factors among the adults residing in an isolated village situated at a rural highland of Nepal. Methods: A cross-sectional survey was conducted in a village located at 3570 m. Each 188 randomly selected participants of age ≥ 18 years old answered a questionnaire and took a full physical exam that included biomedical measurements of glycosylated hemoglobin (HbA1c). Results: The prevalence of intermediate hyperglycemia and DM was 31.6% and 4.6% respectively, and the prevalence of hypoxemia (SpO 2 < 90%) was 27.1%. A multiple logistic regression analysis for factors for the prevalence of glucose intolerance (HbA1c ≥ 6%) revealed older age (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.06-1.16, for every 1 year increase) and SpO 2 (OR for hypoxemia 3.58, 95% CI 1.20-10.68, vs SpO 2 ≥ 90%). Conclusions: Tibetan highlanders in the remote mountainous Mustang valley of Nepal have high prevalence of impaired glucose metabolism which could be related to hypoxemia imposed by the hypoxic conditions of high altitude living.
AB - Background: Epidemiology of noncommunicable diseases (NCDs) such as obesity and diabetes mellitus (DM) are influenced by multiple hosts and environmental factors. This study aims to investigate the prevalence of NCDs and determine their risk factors among the adults residing in an isolated village situated at a rural highland of Nepal. Methods: A cross-sectional survey was conducted in a village located at 3570 m. Each 188 randomly selected participants of age ≥ 18 years old answered a questionnaire and took a full physical exam that included biomedical measurements of glycosylated hemoglobin (HbA1c). Results: The prevalence of intermediate hyperglycemia and DM was 31.6% and 4.6% respectively, and the prevalence of hypoxemia (SpO 2 < 90%) was 27.1%. A multiple logistic regression analysis for factors for the prevalence of glucose intolerance (HbA1c ≥ 6%) revealed older age (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.06-1.16, for every 1 year increase) and SpO 2 (OR for hypoxemia 3.58, 95% CI 1.20-10.68, vs SpO 2 ≥ 90%). Conclusions: Tibetan highlanders in the remote mountainous Mustang valley of Nepal have high prevalence of impaired glucose metabolism which could be related to hypoxemia imposed by the hypoxic conditions of high altitude living.
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U2 - 10.1186/s40101-018-0181-y
DO - 10.1186/s40101-018-0181-y
M3 - Article
C2 - 30157969
AN - SCOPUS:85053024892
SN - 1880-6791
VL - 37
JO - Journal of Physiological Anthropology
JF - Journal of Physiological Anthropology
IS - 1
M1 - 20
ER -
