Current knowledge of intestinal absorption of bioactive peptides

Weilin Shen, Toshiro Matsui

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Peptides have been demonstrated as potentially beneficial compounds against several life-style related diseases such as hypertension, hypercholesterolemia, and atherosclerosis, among others. However, limited research has been carried out on peptide absorption, resulting in a lack of understanding and control of this process. Therefore, this review discusses the recent insights gathered on in vitro and in vivo absorption of peptides across intestinal membranes, into blood circulation. Briefly, some di-/tripeptides permeate through intestinal membranes in their intact forms via peptide transporter systems, while others are vulnerable to protease degradation. Oligopeptides (>tetrapeptides) show a lower transport ability than di-/tripeptides, possibly due to the presence of paracellular tight junctions. The hydrophobicity of peptides (log P) does not seem to influence absorption, while peptide length and degradation of peptides (and peptide sequences) by intestinal proteases may be determinant factors of the absorption process.

Original languageEnglish
Pages (from-to)4306-4314
Number of pages9
JournalFood and Function
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

intestinal absorption
Intestinal Absorption
peptides
Peptides
tripeptides
Peptide Hydrolases
proteinases
peptide transporters
oligopeptides
blood circulation
Oligopeptides
Aptitude
tight junctions
Membranes
degradation
Blood Circulation
Tight Junctions
permeates
hypercholesterolemia
process control

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Current knowledge of intestinal absorption of bioactive peptides. / Shen, Weilin; Matsui, Toshiro.

In: Food and Function, Vol. 8, No. 12, 01.12.2017, p. 4306-4314.

Research output: Contribution to journalReview article

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