TY - JOUR
T1 - Current state and future perspectives of supercritical fluid chromatography
AU - Le, Hung Si
AU - Bamba, Takeshi
N1 - Publisher Copyright:
© 2022
PY - 2022/4
Y1 - 2022/4
N2 - For quite of time, supercritical fluid chromatography (SFC) is expected to make a big revolution in separation technologies. The technique is well known for developing fast and ultrafast high efficiency separation, improving the analytical method greenness. The evolution of SFC technologies (i.e., instrumentations, stationary phases) have shifted dramatically trends in SFC application from the chiral and pharmaceutical analysis toward new diverse application fields including drugs and bioactive compounds, metabolomics, environment, and food science analysis. Moreover, the applications have been greatly expanded toward the analysis of polar and very polar metabolites, resulting in certain successes. This review focuses on the most of SFC related studies during 2020–2021, covering the new development of SFC technologies, recent trends in application and method developments, and more importantly discusses the upcoming perspective regarding the art of supercritical fluid separation.
AB - For quite of time, supercritical fluid chromatography (SFC) is expected to make a big revolution in separation technologies. The technique is well known for developing fast and ultrafast high efficiency separation, improving the analytical method greenness. The evolution of SFC technologies (i.e., instrumentations, stationary phases) have shifted dramatically trends in SFC application from the chiral and pharmaceutical analysis toward new diverse application fields including drugs and bioactive compounds, metabolomics, environment, and food science analysis. Moreover, the applications have been greatly expanded toward the analysis of polar and very polar metabolites, resulting in certain successes. This review focuses on the most of SFC related studies during 2020–2021, covering the new development of SFC technologies, recent trends in application and method developments, and more importantly discusses the upcoming perspective regarding the art of supercritical fluid separation.
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U2 - 10.1016/j.trac.2022.116550
DO - 10.1016/j.trac.2022.116550
M3 - Review article
AN - SCOPUS:85124695231
VL - 149
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
SN - 0165-9936
M1 - 116550
ER -